Frequent HTLV-1 infection in the offspring of Peruvian women with HTLV-1-associated myelopathy/tropical spastic paraparesis or strongyloidiasis

Eduardo Gotuzzo, Joel Moody, Kristien Verdonck, Miguel Cabada, Elsa González, Sonia Van Dooren, Anne Mieke Vandamme, Angélica Terashima, Sten H. Vermund

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objectives. To describe the frequency of HTLV-1 infection among offspring of mothers who had presented with HTLV-1-associated myelopathy /tropical spastic paraparesis (HAM/TSP), strongyloidiasis, or asymptomatic HTLV-1 infection, and to identify factors associated with HTLV-I infection. Methods. In a descriptive study, records were reviewed of HTLV-1-positive women and their offspring who had been tested for HTLV infection at a public hospital in Lima, Peru, from 1989 to 2003. Sons and daughters of women who had presented with strongyloidiasis, HAM/TSP, or asymptomatic infection were eligible for this study. Results. Three hundred seventy subjects were included: 279 were the offspring of 104 mothers presenting with HAM/TSP, 58 were the offspring of 22 mothers with strongyloidiasis, and 33 were the offspring of 26 asymptomatic mothers. Mean age of the offspring at the time of testing was 26 years (standard deviation 12). Nineteen percent of the offspring tested positive for HTLV-1:6% (2/33) of those with asymptomatic mothers, 19% (52/279) among the offspring of mothers with HAM/TSP, and 31% (18/58) among the offspring of mothers presenting with strongyloidiasis On multiple logistic regression analysis, three factors were significantly associated with HTLV-I: (a) duration of breast-feeding (odds ratio [OR] = 15.1; [4.2-54.1] for 12 to 24 months versus less than 6 months breast-feeding); (b) clinical condition of the mother (OR = 8.3 [1.0-65.3] for HAM/TSP and OR = 11.5 [1.4-98.4] for strongyloidiasis in comparison with offspring of asymptomatic mothers); and (c) transfusion history (OR = 5.5 [2.0-15.2]). Conclusions. In addition to known risk factors for HTLV-1 transmission (duration of breast-feeding and history of blood transfusion), maternal HAM/TSP and strongyloidiasis were associated with seropositivity among offspring of HTLV-1-infected mothers.

Original languageEnglish (US)
Pages (from-to)223-230
Number of pages8
JournalRevista Panamericana de Salud Publica/Pan American Journal of Public Health
Volume22
Issue number4
StatePublished - Oct 2007
Externally publishedYes

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Deltaretrovirus Infections
Strongyloidiasis
Tropical Spastic Paraparesis
Human T-lymphotropic virus 1
physical disability
Spinal Cord Diseases
Mothers
Breast Feeding
Odds Ratio
history
risk factor
logistics
regression analysis
Nuclear Family
blood
infection
woman
HTLV-I Infections
Peru
Asymptomatic Infections

Keywords

  • Breast feeding
  • Disease transmission, vertical
  • HTLV-1 infections/transmission
  • HTLV-1-associated myelopathy
  • Human T-lymphotropic virus 1
  • Offspring
  • Paraparesis, tropical spastic
  • Peru
  • Strongyloidiasis

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Geography, Planning and Development

Cite this

Frequent HTLV-1 infection in the offspring of Peruvian women with HTLV-1-associated myelopathy/tropical spastic paraparesis or strongyloidiasis. / Gotuzzo, Eduardo; Moody, Joel; Verdonck, Kristien; Cabada, Miguel; González, Elsa; Van Dooren, Sonia; Vandamme, Anne Mieke; Terashima, Angélica; Vermund, Sten H.

In: Revista Panamericana de Salud Publica/Pan American Journal of Public Health, Vol. 22, No. 4, 10.2007, p. 223-230.

Research output: Contribution to journalArticle

Gotuzzo, Eduardo ; Moody, Joel ; Verdonck, Kristien ; Cabada, Miguel ; González, Elsa ; Van Dooren, Sonia ; Vandamme, Anne Mieke ; Terashima, Angélica ; Vermund, Sten H. / Frequent HTLV-1 infection in the offspring of Peruvian women with HTLV-1-associated myelopathy/tropical spastic paraparesis or strongyloidiasis. In: Revista Panamericana de Salud Publica/Pan American Journal of Public Health. 2007 ; Vol. 22, No. 4. pp. 223-230.
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abstract = "Objectives. To describe the frequency of HTLV-1 infection among offspring of mothers who had presented with HTLV-1-associated myelopathy /tropical spastic paraparesis (HAM/TSP), strongyloidiasis, or asymptomatic HTLV-1 infection, and to identify factors associated with HTLV-I infection. Methods. In a descriptive study, records were reviewed of HTLV-1-positive women and their offspring who had been tested for HTLV infection at a public hospital in Lima, Peru, from 1989 to 2003. Sons and daughters of women who had presented with strongyloidiasis, HAM/TSP, or asymptomatic infection were eligible for this study. Results. Three hundred seventy subjects were included: 279 were the offspring of 104 mothers presenting with HAM/TSP, 58 were the offspring of 22 mothers with strongyloidiasis, and 33 were the offspring of 26 asymptomatic mothers. Mean age of the offspring at the time of testing was 26 years (standard deviation 12). Nineteen percent of the offspring tested positive for HTLV-1:6{\%} (2/33) of those with asymptomatic mothers, 19{\%} (52/279) among the offspring of mothers with HAM/TSP, and 31{\%} (18/58) among the offspring of mothers presenting with strongyloidiasis On multiple logistic regression analysis, three factors were significantly associated with HTLV-I: (a) duration of breast-feeding (odds ratio [OR] = 15.1; [4.2-54.1] for 12 to 24 months versus less than 6 months breast-feeding); (b) clinical condition of the mother (OR = 8.3 [1.0-65.3] for HAM/TSP and OR = 11.5 [1.4-98.4] for strongyloidiasis in comparison with offspring of asymptomatic mothers); and (c) transfusion history (OR = 5.5 [2.0-15.2]). Conclusions. In addition to known risk factors for HTLV-1 transmission (duration of breast-feeding and history of blood transfusion), maternal HAM/TSP and strongyloidiasis were associated with seropositivity among offspring of HTLV-1-infected mothers.",
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T1 - Frequent HTLV-1 infection in the offspring of Peruvian women with HTLV-1-associated myelopathy/tropical spastic paraparesis or strongyloidiasis

AU - Gotuzzo, Eduardo

AU - Moody, Joel

AU - Verdonck, Kristien

AU - Cabada, Miguel

AU - González, Elsa

AU - Van Dooren, Sonia

AU - Vandamme, Anne Mieke

AU - Terashima, Angélica

AU - Vermund, Sten H.

PY - 2007/10

Y1 - 2007/10

N2 - Objectives. To describe the frequency of HTLV-1 infection among offspring of mothers who had presented with HTLV-1-associated myelopathy /tropical spastic paraparesis (HAM/TSP), strongyloidiasis, or asymptomatic HTLV-1 infection, and to identify factors associated with HTLV-I infection. Methods. In a descriptive study, records were reviewed of HTLV-1-positive women and their offspring who had been tested for HTLV infection at a public hospital in Lima, Peru, from 1989 to 2003. Sons and daughters of women who had presented with strongyloidiasis, HAM/TSP, or asymptomatic infection were eligible for this study. Results. Three hundred seventy subjects were included: 279 were the offspring of 104 mothers presenting with HAM/TSP, 58 were the offspring of 22 mothers with strongyloidiasis, and 33 were the offspring of 26 asymptomatic mothers. Mean age of the offspring at the time of testing was 26 years (standard deviation 12). Nineteen percent of the offspring tested positive for HTLV-1:6% (2/33) of those with asymptomatic mothers, 19% (52/279) among the offspring of mothers with HAM/TSP, and 31% (18/58) among the offspring of mothers presenting with strongyloidiasis On multiple logistic regression analysis, three factors were significantly associated with HTLV-I: (a) duration of breast-feeding (odds ratio [OR] = 15.1; [4.2-54.1] for 12 to 24 months versus less than 6 months breast-feeding); (b) clinical condition of the mother (OR = 8.3 [1.0-65.3] for HAM/TSP and OR = 11.5 [1.4-98.4] for strongyloidiasis in comparison with offspring of asymptomatic mothers); and (c) transfusion history (OR = 5.5 [2.0-15.2]). Conclusions. In addition to known risk factors for HTLV-1 transmission (duration of breast-feeding and history of blood transfusion), maternal HAM/TSP and strongyloidiasis were associated with seropositivity among offspring of HTLV-1-infected mothers.

AB - Objectives. To describe the frequency of HTLV-1 infection among offspring of mothers who had presented with HTLV-1-associated myelopathy /tropical spastic paraparesis (HAM/TSP), strongyloidiasis, or asymptomatic HTLV-1 infection, and to identify factors associated with HTLV-I infection. Methods. In a descriptive study, records were reviewed of HTLV-1-positive women and their offspring who had been tested for HTLV infection at a public hospital in Lima, Peru, from 1989 to 2003. Sons and daughters of women who had presented with strongyloidiasis, HAM/TSP, or asymptomatic infection were eligible for this study. Results. Three hundred seventy subjects were included: 279 were the offspring of 104 mothers presenting with HAM/TSP, 58 were the offspring of 22 mothers with strongyloidiasis, and 33 were the offspring of 26 asymptomatic mothers. Mean age of the offspring at the time of testing was 26 years (standard deviation 12). Nineteen percent of the offspring tested positive for HTLV-1:6% (2/33) of those with asymptomatic mothers, 19% (52/279) among the offspring of mothers with HAM/TSP, and 31% (18/58) among the offspring of mothers presenting with strongyloidiasis On multiple logistic regression analysis, three factors were significantly associated with HTLV-I: (a) duration of breast-feeding (odds ratio [OR] = 15.1; [4.2-54.1] for 12 to 24 months versus less than 6 months breast-feeding); (b) clinical condition of the mother (OR = 8.3 [1.0-65.3] for HAM/TSP and OR = 11.5 [1.4-98.4] for strongyloidiasis in comparison with offspring of asymptomatic mothers); and (c) transfusion history (OR = 5.5 [2.0-15.2]). Conclusions. In addition to known risk factors for HTLV-1 transmission (duration of breast-feeding and history of blood transfusion), maternal HAM/TSP and strongyloidiasis were associated with seropositivity among offspring of HTLV-1-infected mothers.

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KW - Disease transmission, vertical

KW - HTLV-1 infections/transmission

KW - HTLV-1-associated myelopathy

KW - Human T-lymphotropic virus 1

KW - Offspring

KW - Paraparesis, tropical spastic

KW - Peru

KW - Strongyloidiasis

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