Abstract
Revealing the factors that shape the genetic structure of avian influenza viruses (AIVs) in wild bird populations is essential to understanding their evolution. However, the relationship between epidemiological dynamics and patterns of genetic diversity in AIV is not well understood, especially at the continental scale. To address this question, we undertook a phylogeographic analysis of complete genome sequences of AIV sampled from wild birds in North America. In particular, we asked whether host species, geographic location or sampling time played the major role in shaping patterns of viral genetic diversity. Strikingly, our analysis revealed no strong species effect, yet a significant viral clustering by time and place of sampling, as well as the circulation of multiple viral lineages in single locations. These results suggest that AIVs can readily infect many of the bird species that share breeding/feeding areas.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 156-161 |
| Number of pages | 6 |
| Journal | Virology |
| Volume | 383 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 5 2009 |
| Externally published | Yes |
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Keywords
- Avian influenza virus
- Epidemiology
- Migration
- Phylogeny
- Population structure
ASJC Scopus subject areas
- Virology
Cite this
Frequent inter-species transmission and geographic subdivision in avian influenza viruses from wild birds. / Chen, Rubing; Holmes, Edward C.
In: Virology, Vol. 383, No. 1, 05.01.2009, p. 156-161.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Frequent inter-species transmission and geographic subdivision in avian influenza viruses from wild birds
AU - Chen, Rubing
AU - Holmes, Edward C.
PY - 2009/1/5
Y1 - 2009/1/5
N2 - Revealing the factors that shape the genetic structure of avian influenza viruses (AIVs) in wild bird populations is essential to understanding their evolution. However, the relationship between epidemiological dynamics and patterns of genetic diversity in AIV is not well understood, especially at the continental scale. To address this question, we undertook a phylogeographic analysis of complete genome sequences of AIV sampled from wild birds in North America. In particular, we asked whether host species, geographic location or sampling time played the major role in shaping patterns of viral genetic diversity. Strikingly, our analysis revealed no strong species effect, yet a significant viral clustering by time and place of sampling, as well as the circulation of multiple viral lineages in single locations. These results suggest that AIVs can readily infect many of the bird species that share breeding/feeding areas.
AB - Revealing the factors that shape the genetic structure of avian influenza viruses (AIVs) in wild bird populations is essential to understanding their evolution. However, the relationship between epidemiological dynamics and patterns of genetic diversity in AIV is not well understood, especially at the continental scale. To address this question, we undertook a phylogeographic analysis of complete genome sequences of AIV sampled from wild birds in North America. In particular, we asked whether host species, geographic location or sampling time played the major role in shaping patterns of viral genetic diversity. Strikingly, our analysis revealed no strong species effect, yet a significant viral clustering by time and place of sampling, as well as the circulation of multiple viral lineages in single locations. These results suggest that AIVs can readily infect many of the bird species that share breeding/feeding areas.
KW - Avian influenza virus
KW - Epidemiology
KW - Migration
KW - Phylogeny
KW - Population structure
UR - http://www.scopus.com/inward/record.url?scp=57049130912&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=57049130912&partnerID=8YFLogxK
U2 - 10.1016/j.virol.2008.10.015
DO - 10.1016/j.virol.2008.10.015
M3 - Article
VL - 383
SP - 156
EP - 161
JO - Virology
JF - Virology
SN - 0042-6822
IS - 1
ER -