From bench to almost bedside: The long road to a licensed ebola virus vaccine

Gary Wong, Emelissa J. Mendoza, Francis A. Plummer, George F. Gao, Gary P. Kobinger, Xiangguo Qiu

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations

Abstract

Introduction: The Ebola virus (EBOV) disease epidemic during 2014–16 in West Africa has accelerated the clinical development of several vaccine candidates that have demonstrated efficacy in the gold standard nonhuman primate (NHP) model, namely cynomolgus macaques. Areas covered: This review discusses the pre-clinical research and if available, clinical evaluation of the currently available EBOV vaccine candidates, while emphasizing the translatability of pre-clinical data generated in the NHP model to clinical data in humans. Expert opinion: Despite the existence of many successful EBOV vaccine candidates in the pre-clinical stages, only two platforms became the focus of Phase 2/3 efficacy trials in Liberia, Sierra Leone, and Guinea near the peak of the epidemic: the Vesicular stomatitis virus (VSV)-vectored vaccine and the chimpanzee adenovirus type 3 (ChAd3)-vectored vaccine. The results of three distinct clinical trials involving these candidates may soon pave the way for a licensed, safe and efficacious EBOV vaccine to help combat future epidemics.

Original languageEnglish (US)
Pages (from-to)159-173
Number of pages15
JournalExpert Opinion on Biological Therapy
Volume18
Issue number2
DOIs
StatePublished - Nov 17 2018
Externally publishedYes

Keywords

  • Clinical trials
  • Ebola virus
  • Nonhuman primates
  • Vaccines

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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