TY - JOUR
T1 - Frustrative Nonreward
T2 - Behavior, Circuits, Neurochemistry, and Disorders
AU - Papini, Mauricio R.
AU - Green, Thomas A.
AU - Contreras, Yorkiris Mármol
AU - Torres, Carmen
AU - Ogawa, Masaaki
AU - Li, Zheng
N1 - Publisher Copyright:
© 2024 the authors.
PY - 2024/10/2
Y1 - 2024/10/2
N2 - The surprising omission or reduction of vital resources (food, fluid, social partners) can induce an aversive emotion known as frustrative nonreward (FNR), which can influence subsequent behavior and physiology. FNR is an integral mediator of irritability/ aggression, motivation (substance use disorders, depression), anxiety/fear/threat, learning/conditioning, and social behavior. Despite substantial progress in the study of FNR during the twentieth century, research lagged in the later part of the century and into the early twenty-first century until the National Institute of Mental Health’s Research Domain Criteria initiative included FNR and loss as components of the negative valence domain. This led to a renaissance of new research and paradigms relevant to basic and clinical science alike. The COVID-19 pandemic’s extensive individual and social restrictions were correlated with increased drug and alcohol use, social conflict, irritability, and suicide, all potential consequences of FNR. This article highlights animal models related to these psychiatric disorders and symptoms and presents recent advances in identifying the brain regions and neurotransmitters implicated.
AB - The surprising omission or reduction of vital resources (food, fluid, social partners) can induce an aversive emotion known as frustrative nonreward (FNR), which can influence subsequent behavior and physiology. FNR is an integral mediator of irritability/ aggression, motivation (substance use disorders, depression), anxiety/fear/threat, learning/conditioning, and social behavior. Despite substantial progress in the study of FNR during the twentieth century, research lagged in the later part of the century and into the early twenty-first century until the National Institute of Mental Health’s Research Domain Criteria initiative included FNR and loss as components of the negative valence domain. This led to a renaissance of new research and paradigms relevant to basic and clinical science alike. The COVID-19 pandemic’s extensive individual and social restrictions were correlated with increased drug and alcohol use, social conflict, irritability, and suicide, all potential consequences of FNR. This article highlights animal models related to these psychiatric disorders and symptoms and presents recent advances in identifying the brain regions and neurotransmitters implicated.
KW - consummatory successive negative contrast
KW - dopamine
KW - drug use disorder
KW - frustrated nonreward
KW - irritability
UR - http://www.scopus.com/inward/record.url?scp=85205527079&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85205527079&partnerID=8YFLogxK
U2 - 10.1523/JNEUROSCI.1021-24.2024
DO - 10.1523/JNEUROSCI.1021-24.2024
M3 - Article
C2 - 39358023
AN - SCOPUS:85205527079
SN - 0270-6474
VL - 44
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 40
M1 - e1021242024
ER -