Frustrative Nonreward: Behavior, Circuits, Neurochemistry, and Disorders

Mauricio R. Papini, Thomas A. Green, Yorkiris Mármol Contreras, Carmen Torres, Masaaki Ogawa, Zheng Li

Research output: Contribution to journalArticlepeer-review

Abstract

The surprising omission or reduction of vital resources (food, fluid, social partners) can induce an aversive emotion known as frustrative nonreward (FNR), which can influence subsequent behavior and physiology. FNR is an integral mediator of irritability/ aggression, motivation (substance use disorders, depression), anxiety/fear/threat, learning/conditioning, and social behavior. Despite substantial progress in the study of FNR during the twentieth century, research lagged in the later part of the century and into the early twenty-first century until the National Institute of Mental Health’s Research Domain Criteria initiative included FNR and loss as components of the negative valence domain. This led to a renaissance of new research and paradigms relevant to basic and clinical science alike. The COVID-19 pandemic’s extensive individual and social restrictions were correlated with increased drug and alcohol use, social conflict, irritability, and suicide, all potential consequences of FNR. This article highlights animal models related to these psychiatric disorders and symptoms and presents recent advances in identifying the brain regions and neurotransmitters implicated.

Original languageEnglish (US)
Article numbere1021242024
JournalJournal of Neuroscience
Volume44
Issue number40
DOIs
StatePublished - Oct 2 2024
Externally publishedYes

Keywords

  • consummatory successive negative contrast
  • dopamine
  • drug use disorder
  • frustrated nonreward
  • irritability

ASJC Scopus subject areas

  • General Neuroscience

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