FSH and LH Response in the Rat After Intravenous, Intracarotid or Subcutaneous Administration of LH-RH

George H. Greeley, M. B. Allen, V. B. Mahesh

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Using permanent stalk sectioned ovariectomized rats and 4 day cyclic rats on the day of estrus, the effect of either subcutaneous or acute intravenous intracarotid luteinizing hormone releasing hormone (LH RH) was examined. After a subcutaneous injection of LH RH both follicle stimulating hormone (FSH) and LH release occurred, whereas only LH levels increased after an intravenous or intraarterial injection. These results suggest that prolonged exposure of the pituitary to LH RH is necessary for FSH discharge, or that LH RH may undergo metabolic modifications resulting in greater FSH releasing activity.

Original languageEnglish (US)
Pages (from-to)859-862
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume147
Issue number3
DOIs
StatePublished - Dec 1974
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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