FSH and LH Response in the Rat After Intravenous, Intracarotid or Subcutaneous Administration of LH-RH

George H. Greeley; M. B. Allen; V. B. Mahesh

doi:10.3181/00379727-147-38456

FSH and LH Response in the Rat After Intravenous, Intracarotid or Subcutaneous Administration of LH-RH

George H. Greeley, M. B. Allen, V. B. Mahesh

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Using permanent stalk sectioned ovariectomized rats and 4 day cyclic rats on the day of estrus, the effect of either subcutaneous or acute intravenous intracarotid luteinizing hormone releasing hormone (LH RH) was examined. After a subcutaneous injection of LH RH both follicle stimulating hormone (FSH) and LH release occurred, whereas only LH levels increased after an intravenous or intraarterial injection. These results suggest that prolonged exposure of the pituitary to LH RH is necessary for FSH discharge, or that LH RH may undergo metabolic modifications resulting in greater FSH releasing activity.

Original language	English (US)
Pages (from-to)	859-862
Number of pages	4
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	147
Issue number	3
DOIs	https://doi.org/10.3181/00379727-147-38456
State	Published - Dec 1974
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.3181/00379727-147-38456

Cite this

@article{926cf4e9a6c242dfbae6aaf1b49958af,

title = "FSH and LH Response in the Rat After Intravenous, Intracarotid or Subcutaneous Administration of LH-RH",

abstract = "Using permanent stalk sectioned ovariectomized rats and 4 day cyclic rats on the day of estrus, the effect of either subcutaneous or acute intravenous intracarotid luteinizing hormone releasing hormone (LH RH) was examined. After a subcutaneous injection of LH RH both follicle stimulating hormone (FSH) and LH release occurred, whereas only LH levels increased after an intravenous or intraarterial injection. These results suggest that prolonged exposure of the pituitary to LH RH is necessary for FSH discharge, or that LH RH may undergo metabolic modifications resulting in greater FSH releasing activity.",

author = "Greeley, {George H.} and Allen, {M. B.} and Mahesh, {V. B.}",

year = "1974",

month = dec,

doi = "10.3181/00379727-147-38456",

language = "English (US)",

volume = "147",

pages = "859--862",

journal = "Proceedings of the Society for Experimental Biology and Medicine",

issn = "0037-9727",

publisher = "Frontiers Media SA",

number = "3",

}

TY - JOUR

T1 - FSH and LH Response in the Rat After Intravenous, Intracarotid or Subcutaneous Administration of LH-RH

AU - Greeley, George H.

AU - Allen, M. B.

AU - Mahesh, V. B.

PY - 1974/12

Y1 - 1974/12

N2 - Using permanent stalk sectioned ovariectomized rats and 4 day cyclic rats on the day of estrus, the effect of either subcutaneous or acute intravenous intracarotid luteinizing hormone releasing hormone (LH RH) was examined. After a subcutaneous injection of LH RH both follicle stimulating hormone (FSH) and LH release occurred, whereas only LH levels increased after an intravenous or intraarterial injection. These results suggest that prolonged exposure of the pituitary to LH RH is necessary for FSH discharge, or that LH RH may undergo metabolic modifications resulting in greater FSH releasing activity.

AB - Using permanent stalk sectioned ovariectomized rats and 4 day cyclic rats on the day of estrus, the effect of either subcutaneous or acute intravenous intracarotid luteinizing hormone releasing hormone (LH RH) was examined. After a subcutaneous injection of LH RH both follicle stimulating hormone (FSH) and LH release occurred, whereas only LH levels increased after an intravenous or intraarterial injection. These results suggest that prolonged exposure of the pituitary to LH RH is necessary for FSH discharge, or that LH RH may undergo metabolic modifications resulting in greater FSH releasing activity.

UR - http://www.scopus.com/inward/record.url?scp=0016318243&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016318243&partnerID=8YFLogxK

U2 - 10.3181/00379727-147-38456

DO - 10.3181/00379727-147-38456

M3 - Article

C2 - 4614271

AN - SCOPUS:0016318243

SN - 0037-9727

VL - 147

SP - 859

EP - 862

JO - Proceedings of the Society for Experimental Biology and Medicine

JF - Proceedings of the Society for Experimental Biology and Medicine

IS - 3

ER -

FSH and LH Response in the Rat After Intravenous, Intracarotid or Subcutaneous Administration of LH-RH

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this