FSH and LH Response in the Rat After Intravenous, Intracarotid or Subcutaneous Administration of LH-RH

George H. Greeley; M. B. Allen; V. B. Mahesh

doi:10.3181/00379727-147-38456

FSH and LH Response in the Rat After Intravenous, Intracarotid or Subcutaneous Administration of LH-RH

George H. Greeley, M. B. Allen, V. B. Mahesh

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6 Scopus citations

Abstract

Using permanent stalk sectioned ovariectomized rats and 4 day cyclic rats on the day of estrus, the effect of either subcutaneous or acute intravenous intracarotid luteinizing hormone releasing hormone (LH RH) was examined. After a subcutaneous injection of LH RH both follicle stimulating hormone (FSH) and LH release occurred, whereas only LH levels increased after an intravenous or intraarterial injection. These results suggest that prolonged exposure of the pituitary to LH RH is necessary for FSH discharge, or that LH RH may undergo metabolic modifications resulting in greater FSH releasing activity.

Original language	English (US)
Pages (from-to)	859-862
Number of pages	4
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	147
Issue number	3
DOIs	https://doi.org/10.3181/00379727-147-38456
State	Published - Dec 1974

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Biochemistry, Genetics and Molecular Biology(all)

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title = "FSH and LH Response in the Rat After Intravenous, Intracarotid or Subcutaneous Administration of LH-RH",

abstract = "Using permanent stalk sectioned ovariectomized rats and 4 day cyclic rats on the day of estrus, the effect of either subcutaneous or acute intravenous intracarotid luteinizing hormone releasing hormone (LH RH) was examined. After a subcutaneous injection of LH RH both follicle stimulating hormone (FSH) and LH release occurred, whereas only LH levels increased after an intravenous or intraarterial injection. These results suggest that prolonged exposure of the pituitary to LH RH is necessary for FSH discharge, or that LH RH may undergo metabolic modifications resulting in greater FSH releasing activity.",

author = "Greeley, {George H.} and Allen, {M. B.} and Mahesh, {V. B.}",

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AU - Mahesh, V. B.

PY - 1974/12

Y1 - 1974/12

N2 - Using permanent stalk sectioned ovariectomized rats and 4 day cyclic rats on the day of estrus, the effect of either subcutaneous or acute intravenous intracarotid luteinizing hormone releasing hormone (LH RH) was examined. After a subcutaneous injection of LH RH both follicle stimulating hormone (FSH) and LH release occurred, whereas only LH levels increased after an intravenous or intraarterial injection. These results suggest that prolonged exposure of the pituitary to LH RH is necessary for FSH discharge, or that LH RH may undergo metabolic modifications resulting in greater FSH releasing activity.

AB - Using permanent stalk sectioned ovariectomized rats and 4 day cyclic rats on the day of estrus, the effect of either subcutaneous or acute intravenous intracarotid luteinizing hormone releasing hormone (LH RH) was examined. After a subcutaneous injection of LH RH both follicle stimulating hormone (FSH) and LH release occurred, whereas only LH levels increased after an intravenous or intraarterial injection. These results suggest that prolonged exposure of the pituitary to LH RH is necessary for FSH discharge, or that LH RH may undergo metabolic modifications resulting in greater FSH releasing activity.

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FSH and LH Response in the Rat After Intravenous, Intracarotid or Subcutaneous Administration of LH-RH

Abstract

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