Using permanent stalk sectioned ovariectomized rats and 4 day cyclic rats on the day of estrus, the effect of either subcutaneous or acute intravenous intracarotid luteinizing hormone releasing hormone (LH RH) was examined. After a subcutaneous injection of LH RH both follicle stimulating hormone (FSH) and LH release occurred, whereas only LH levels increased after an intravenous or intraarterial injection. These results suggest that prolonged exposure of the pituitary to LH RH is necessary for FSH discharge, or that LH RH may undergo metabolic modifications resulting in greater FSH releasing activity.
|Original language||English (US)|
|Number of pages||4|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - Dec 1974|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)