Functional analysis of the integrator subunit 12 identifies a microdomain that mediates activation of the drosophila integrator complex

Jiandong Chen, Bernhard Waltenspiel, William D. Warren, Eric J. Wagner

Research output: Contribution to journalArticle

12 Scopus citations


Background: Small nuclear RNA (snRNA) 3′ end processing is carried out by the poorly understood integrator complex. Results: An essential microdomain within IntS12 binds IntS1 and is required for integrator complex activity. Conclusion: A small binding interface between the largest and smallest integrator subunits is critical for snRNA processing. Significance: These data uncover the unexpected findings that the IntS12 PHD finger is nearly dispensable for snRNA processing, whereas a microdomain is required.

Original languageEnglish (US)
Pages (from-to)4867-4877
Number of pages11
JournalJournal of Biological Chemistry
Issue number7
StatePublished - Feb 15 2013
Externally publishedYes


ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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