Abstract
The decline in the function of the growth hormone-releasing hormone, growth hormone, insulin-like growth factor (GHRH-GH-IGF) axis has been termed the somatopause. Many of the catabolic sequelae seen in normal aging has been attributed to this decrease in circulating GH and IGF-I. In order to provide hormone replacement therapy for the somatopause, elderly subjects have been treated with GH, IGF-I, or both hormones together. Whereas numerous beneficial effects on body composition, strength, and quality of life have been reported in some studies, other studies have reported only marginal functional improvements. Moreover, it is clear that both hormones can cause significant morbidity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 73-76 |
| Number of pages | 4 |
| Journal | Endocrine |
| Volume | 7 |
| Issue number | 1 |
| State | Published - 1997 |
| Externally published | Yes |
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Keywords
- Body composition
- GH
- IGF-I
- Somatopause
ASJC Scopus subject areas
- Endocrinology
Cite this
Functional Consequences of the Somatopause and its Treatment. / Hoffman, Andrew R.; Lieberman, Steven; Butterfield, Gail; Thompson, Janice; Hintz, Raymond L.; Ceda, Gian Paolo; Marcus, Robert.
In: Endocrine, Vol. 7, No. 1, 1997, p. 73-76.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Functional Consequences of the Somatopause and its Treatment
AU - Hoffman, Andrew R.
AU - Lieberman, Steven
AU - Butterfield, Gail
AU - Thompson, Janice
AU - Hintz, Raymond L.
AU - Ceda, Gian Paolo
AU - Marcus, Robert
PY - 1997
Y1 - 1997
N2 - The decline in the function of the growth hormone-releasing hormone, growth hormone, insulin-like growth factor (GHRH-GH-IGF) axis has been termed the somatopause. Many of the catabolic sequelae seen in normal aging has been attributed to this decrease in circulating GH and IGF-I. In order to provide hormone replacement therapy for the somatopause, elderly subjects have been treated with GH, IGF-I, or both hormones together. Whereas numerous beneficial effects on body composition, strength, and quality of life have been reported in some studies, other studies have reported only marginal functional improvements. Moreover, it is clear that both hormones can cause significant morbidity.
AB - The decline in the function of the growth hormone-releasing hormone, growth hormone, insulin-like growth factor (GHRH-GH-IGF) axis has been termed the somatopause. Many of the catabolic sequelae seen in normal aging has been attributed to this decrease in circulating GH and IGF-I. In order to provide hormone replacement therapy for the somatopause, elderly subjects have been treated with GH, IGF-I, or both hormones together. Whereas numerous beneficial effects on body composition, strength, and quality of life have been reported in some studies, other studies have reported only marginal functional improvements. Moreover, it is clear that both hormones can cause significant morbidity.
KW - Body composition
KW - GH
KW - IGF-I
KW - Somatopause
UR - http://www.scopus.com/inward/record.url?scp=0031196695&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031196695&partnerID=8YFLogxK
M3 - Article
VL - 7
SP - 73
EP - 76
JO - Endocrine
JF - Endocrine
SN - 0969-711X
IS - 1
ER -