Functional interferon system is required for clearance of Lassa virus

Nadezhda E Yun, Allison L. Poussard, Alexey V. Seregin, Aida G. Walker, Jennifer K. Smith, Judith F. Aronson, Jeanon N. Smith, Lynn Soong, Slobodan Paessler

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Lassa virus (LASV) is the causative agent of Lassa hemorrhagic fever (LF) in humans, a deadly disease endemic to West Africa that results in 5,000 to 10,000 deaths annually. Here we present results demonstrating that functional type I and type II interferon (IFN) signaling is required for efficient control of LASV dissemination and clearance.

Original languageEnglish (US)
Pages (from-to)3389-3392
Number of pages4
JournalJournal of virology
Volume86
Issue number6
DOIs
StatePublished - Mar 2012

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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  • Cite this

    Yun, N. E., Poussard, A. L., Seregin, A. V., Walker, A. G., Smith, J. K., Aronson, J. F., Smith, J. N., Soong, L., & Paessler, S. (2012). Functional interferon system is required for clearance of Lassa virus. Journal of virology, 86(6), 3389-3392. https://doi.org/10.1128/JVI.06284-11