Functional interferon system is required for clearance of Lassa virus

Nadezhda E. Yun, Allison L. Poussard, Alexey V. Seregin, Aida G. Walker, Jennifer K. Smith, Judith Aronson, Jeanon N. Smith, Lynn Soong, Slobodan Paessler

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Lassa virus (LASV) is the causative agent of Lassa hemorrhagic fever (LF) in humans, a deadly disease endemic to West Africa that results in 5,000 to 10,000 deaths annually. Here we present results demonstrating that functional type I and type II interferon (IFN) signaling is required for efficient control of LASV dissemination and clearance.

Original languageEnglish (US)
Pages (from-to)3389-3392
Number of pages4
JournalJournal of Virology
Volume86
Issue number6
DOIs
StatePublished - Mar 2012

Fingerprint

Lassa virus
interferons
Interferons
Lassa Fever
Endemic Diseases
Interferon Type I
Western Africa
interferon-gamma
Interferon-gamma
fever
death

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Functional interferon system is required for clearance of Lassa virus. / Yun, Nadezhda E.; Poussard, Allison L.; Seregin, Alexey V.; Walker, Aida G.; Smith, Jennifer K.; Aronson, Judith; Smith, Jeanon N.; Soong, Lynn; Paessler, Slobodan.

In: Journal of Virology, Vol. 86, No. 6, 03.2012, p. 3389-3392.

Research output: Contribution to journalArticle

Yun, NE, Poussard, AL, Seregin, AV, Walker, AG, Smith, JK, Aronson, J, Smith, JN, Soong, L & Paessler, S 2012, 'Functional interferon system is required for clearance of Lassa virus', Journal of Virology, vol. 86, no. 6, pp. 3389-3392. https://doi.org/10.1128/JVI.06284-11
Yun NE, Poussard AL, Seregin AV, Walker AG, Smith JK, Aronson J et al. Functional interferon system is required for clearance of Lassa virus. Journal of Virology. 2012 Mar;86(6):3389-3392. https://doi.org/10.1128/JVI.06284-11
Yun, Nadezhda E. ; Poussard, Allison L. ; Seregin, Alexey V. ; Walker, Aida G. ; Smith, Jennifer K. ; Aronson, Judith ; Smith, Jeanon N. ; Soong, Lynn ; Paessler, Slobodan. / Functional interferon system is required for clearance of Lassa virus. In: Journal of Virology. 2012 ; Vol. 86, No. 6. pp. 3389-3392.
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