Functional interferon system is required for clearance of Lassa virus

Nadezhda E. Yun; Allison L. Poussard; Alexey V. Seregin; Aida G. Walker; Jennifer K. Smith; Judith F. Aronson; Jeanon N. Smith; Lynn Soong; Slobodan Paessler

doi:10.1128/JVI.06284-11

Functional interferon system is required for clearance of Lassa virus

Nadezhda E. Yun, Allison L. Poussard, Alexey V. Seregin, Aida G. Walker, Jennifer K. Smith, Judith F. Aronson, Jeanon N. Smith, Lynn Soong, Slobodan Paessler

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Lassa virus (LASV) is the causative agent of Lassa hemorrhagic fever (LF) in humans, a deadly disease endemic to West Africa that results in 5,000 to 10,000 deaths annually. Here we present results demonstrating that functional type I and type II interferon (IFN) signaling is required for efficient control of LASV dissemination and clearance.

Original language	English (US)
Pages (from-to)	3389-3392
Number of pages	4
Journal	Journal of virology
Volume	86
Issue number	6
DOIs	https://doi.org/10.1128/JVI.06284-11
State	Published - Mar 2012

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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10.1128/JVI.06284-11

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abstract = "Lassa virus (LASV) is the causative agent of Lassa hemorrhagic fever (LF) in humans, a deadly disease endemic to West Africa that results in 5,000 to 10,000 deaths annually. Here we present results demonstrating that functional type I and type II interferon (IFN) signaling is required for efficient control of LASV dissemination and clearance.",

author = "Yun, {Nadezhda E.} and Poussard, {Allison L.} and Seregin, {Alexey V.} and Walker, {Aida G.} and Smith, {Jennifer K.} and Aronson, {Judith F.} and Smith, {Jeanon N.} and Lynn Soong and Slobodan Paessler",

year = "2012",

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AU - Yun, Nadezhda E.

AU - Poussard, Allison L.

AU - Seregin, Alexey V.

AU - Walker, Aida G.

AU - Smith, Jennifer K.

AU - Aronson, Judith F.

AU - Smith, Jeanon N.

AU - Soong, Lynn

AU - Paessler, Slobodan

PY - 2012/3

Y1 - 2012/3

N2 - Lassa virus (LASV) is the causative agent of Lassa hemorrhagic fever (LF) in humans, a deadly disease endemic to West Africa that results in 5,000 to 10,000 deaths annually. Here we present results demonstrating that functional type I and type II interferon (IFN) signaling is required for efficient control of LASV dissemination and clearance.

AB - Lassa virus (LASV) is the causative agent of Lassa hemorrhagic fever (LF) in humans, a deadly disease endemic to West Africa that results in 5,000 to 10,000 deaths annually. Here we present results demonstrating that functional type I and type II interferon (IFN) signaling is required for efficient control of LASV dissemination and clearance.

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JO - Journal of virology

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Functional interferon system is required for clearance of Lassa virus

Abstract

ASJC Scopus subject areas

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