Functional interferon system is required for clearance of Lassa virus

Nadezhda E. Yun, Allison L. Poussard, Alexey V. Seregin, Aida G. Walker, Jennifer K. Smith, Judith F. Aronson, Jeanon N. Smith, Lynn Soong, Slobodan Paessler

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Lassa virus (LASV) is the causative agent of Lassa hemorrhagic fever (LF) in humans, a deadly disease endemic to West Africa that results in 5,000 to 10,000 deaths annually. Here we present results demonstrating that functional type I and type II interferon (IFN) signaling is required for efficient control of LASV dissemination and clearance.

Original languageEnglish (US)
Pages (from-to)3389-3392
Number of pages4
JournalJournal of virology
Volume86
Issue number6
DOIs
StatePublished - Mar 2012

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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