Functional interferon system is required for clearance of Lassa virus

Nadezhda E. Yun; Allison L. Poussard; Alexey V. Seregin; Aida G. Walker; Jennifer K. Smith; Judith F. Aronson; Jeanon N. Smith; Lynn Soong; Slobodan Paessler

doi:10.1128/JVI.06284-11

Functional interferon system is required for clearance of Lassa virus

Nadezhda E. Yun
, Allison L. Poussard
, Alexey V. Seregin
, Aida G. Walker
, Jennifer K. Smith
, Judith F. Aronson
, Jeanon N. Smith
, Lynn Soong
, Slobodan Paessler

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Lassa virus (LASV) is the causative agent of Lassa hemorrhagic fever (LF) in humans, a deadly disease endemic to West Africa that results in 5,000 to 10,000 deaths annually. Here we present results demonstrating that functional type I and type II interferon (IFN) signaling is required for efficient control of LASV dissemination and clearance.

Original language	English (US)
Pages (from-to)	3389-3392
Number of pages	4
Journal	Journal of virology
Volume	86
Issue number	6
DOIs	https://doi.org/10.1128/JVI.06284-11
State	Published - Mar 2012

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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10.1128/JVI.06284-11

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abstract = "Lassa virus (LASV) is the causative agent of Lassa hemorrhagic fever (LF) in humans, a deadly disease endemic to West Africa that results in 5,000 to 10,000 deaths annually. Here we present results demonstrating that functional type I and type II interferon (IFN) signaling is required for efficient control of LASV dissemination and clearance.",

author = "Yun, \{Nadezhda E.\} and Poussard, \{Allison L.\} and Seregin, \{Alexey V.\} and Walker, \{Aida G.\} and Smith, \{Jennifer K.\} and Aronson, \{Judith F.\} and Smith, \{Jeanon N.\} and Lynn Soong and Slobodan Paessler",

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AU - Yun, Nadezhda E.

AU - Poussard, Allison L.

AU - Seregin, Alexey V.

AU - Walker, Aida G.

AU - Smith, Jennifer K.

AU - Aronson, Judith F.

AU - Smith, Jeanon N.

AU - Soong, Lynn

AU - Paessler, Slobodan

PY - 2012/3

Y1 - 2012/3

N2 - Lassa virus (LASV) is the causative agent of Lassa hemorrhagic fever (LF) in humans, a deadly disease endemic to West Africa that results in 5,000 to 10,000 deaths annually. Here we present results demonstrating that functional type I and type II interferon (IFN) signaling is required for efficient control of LASV dissemination and clearance.

AB - Lassa virus (LASV) is the causative agent of Lassa hemorrhagic fever (LF) in humans, a deadly disease endemic to West Africa that results in 5,000 to 10,000 deaths annually. Here we present results demonstrating that functional type I and type II interferon (IFN) signaling is required for efficient control of LASV dissemination and clearance.

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UR - https://www.scopus.com/pages/publications/84863239710#tab=citedBy

U2 - 10.1128/JVI.06284-11

DO - 10.1128/JVI.06284-11

M3 - Article

C2 - 22238311

AN - SCOPUS:84863239710

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SP - 3389

EP - 3392

JO - Journal of virology

JF - Journal of virology

IS - 6

ER -

Functional interferon system is required for clearance of Lassa virus

Abstract

ASJC Scopus subject areas

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