Functionalized gold nanorods-for molecular optoacoustic imaging

Mohammad Eghtedari, Alexander Oraevsky, Andre Conjusteau, John A. Copland, Nicholas A. Kotov, Massoud Motamedi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

The development of gold nanoparticles for molecular optoacoustic imaging is a very promising area of research and development. Enhancement of optoacoustic imaging for molecular detection of tumors requires the engineering of nanoparticles with geometrical and molecular features that can enhance selective targeting of malignant cells while optimizing the sensitivity of optoacoustic detection. In this article, cylindrical gold nanoparticles (i.e. gold nanorods) were fabricated with a plasmon resonance frequency in the near infra-red region of the spectrum, where deep irradiation of tissue is possible using an Alexandrite laser. Gold nanorods (Au-NRs) were functionalized by covalent attachment of Poly(ethylene glycol) to enhance their biocompatibility. These particles were further functionalized with the aim of targeting breast cancer cells using monoclonal antibodies that binds to Her2/neu receptors, which are over expressed on the surface of breast cancer cells. A custom Laser Optoacoustic Imaging System (LOIS) was designed and employed to image nanoparticle-targeted cancer cells in a phantom and PEGylated Au-NRs that were injected subcutaneously into a nude mouse. The results of our experiments show that functionalized Au-NRs with a plasmon resonance frequency at near infra-red region of the spectrum can be detected and imaged in vivo using laser optoacoustic imaging system.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6437
DOIs
StatePublished - 2007
EventPhotons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics - San Jose, CA, United States
Duration: Jan 21 2007Jan 24 2007

Other

OtherPhotons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
CountryUnited States
CitySan Jose, CA
Period1/21/071/24/07

Fingerprint

Photoacoustic effect
Nanorods
Gold
Imaging techniques
Nanoparticles
Cells
Imaging systems
Lasers
Infrared radiation
Monoclonal antibodies
Biocompatibility
Polyethylene glycols
Tumors
Irradiation
Tissue
Experiments

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Eghtedari, M., Oraevsky, A., Conjusteau, A., Copland, J. A., Kotov, N. A., & Motamedi, M. (2007). Functionalized gold nanorods-for molecular optoacoustic imaging. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 6437). [64370G] https://doi.org/10.1117/12.716380

Functionalized gold nanorods-for molecular optoacoustic imaging. / Eghtedari, Mohammad; Oraevsky, Alexander; Conjusteau, Andre; Copland, John A.; Kotov, Nicholas A.; Motamedi, Massoud.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6437 2007. 64370G.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Eghtedari, M, Oraevsky, A, Conjusteau, A, Copland, JA, Kotov, NA & Motamedi, M 2007, Functionalized gold nanorods-for molecular optoacoustic imaging. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 6437, 64370G, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, San Jose, CA, United States, 1/21/07. https://doi.org/10.1117/12.716380
Eghtedari M, Oraevsky A, Conjusteau A, Copland JA, Kotov NA, Motamedi M. Functionalized gold nanorods-for molecular optoacoustic imaging. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6437. 2007. 64370G https://doi.org/10.1117/12.716380
Eghtedari, Mohammad ; Oraevsky, Alexander ; Conjusteau, Andre ; Copland, John A. ; Kotov, Nicholas A. ; Motamedi, Massoud. / Functionalized gold nanorods-for molecular optoacoustic imaging. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6437 2007.
@inproceedings{60a2bbd124044e12885dc0ab7a0c514a,
title = "Functionalized gold nanorods-for molecular optoacoustic imaging",
abstract = "The development of gold nanoparticles for molecular optoacoustic imaging is a very promising area of research and development. Enhancement of optoacoustic imaging for molecular detection of tumors requires the engineering of nanoparticles with geometrical and molecular features that can enhance selective targeting of malignant cells while optimizing the sensitivity of optoacoustic detection. In this article, cylindrical gold nanoparticles (i.e. gold nanorods) were fabricated with a plasmon resonance frequency in the near infra-red region of the spectrum, where deep irradiation of tissue is possible using an Alexandrite laser. Gold nanorods (Au-NRs) were functionalized by covalent attachment of Poly(ethylene glycol) to enhance their biocompatibility. These particles were further functionalized with the aim of targeting breast cancer cells using monoclonal antibodies that binds to Her2/neu receptors, which are over expressed on the surface of breast cancer cells. A custom Laser Optoacoustic Imaging System (LOIS) was designed and employed to image nanoparticle-targeted cancer cells in a phantom and PEGylated Au-NRs that were injected subcutaneously into a nude mouse. The results of our experiments show that functionalized Au-NRs with a plasmon resonance frequency at near infra-red region of the spectrum can be detected and imaged in vivo using laser optoacoustic imaging system.",
author = "Mohammad Eghtedari and Alexander Oraevsky and Andre Conjusteau and Copland, {John A.} and Kotov, {Nicholas A.} and Massoud Motamedi",
year = "2007",
doi = "10.1117/12.716380",
language = "English (US)",
isbn = "081946550X",
volume = "6437",
booktitle = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

}

TY - GEN

T1 - Functionalized gold nanorods-for molecular optoacoustic imaging

AU - Eghtedari, Mohammad

AU - Oraevsky, Alexander

AU - Conjusteau, Andre

AU - Copland, John A.

AU - Kotov, Nicholas A.

AU - Motamedi, Massoud

PY - 2007

Y1 - 2007

N2 - The development of gold nanoparticles for molecular optoacoustic imaging is a very promising area of research and development. Enhancement of optoacoustic imaging for molecular detection of tumors requires the engineering of nanoparticles with geometrical and molecular features that can enhance selective targeting of malignant cells while optimizing the sensitivity of optoacoustic detection. In this article, cylindrical gold nanoparticles (i.e. gold nanorods) were fabricated with a plasmon resonance frequency in the near infra-red region of the spectrum, where deep irradiation of tissue is possible using an Alexandrite laser. Gold nanorods (Au-NRs) were functionalized by covalent attachment of Poly(ethylene glycol) to enhance their biocompatibility. These particles were further functionalized with the aim of targeting breast cancer cells using monoclonal antibodies that binds to Her2/neu receptors, which are over expressed on the surface of breast cancer cells. A custom Laser Optoacoustic Imaging System (LOIS) was designed and employed to image nanoparticle-targeted cancer cells in a phantom and PEGylated Au-NRs that were injected subcutaneously into a nude mouse. The results of our experiments show that functionalized Au-NRs with a plasmon resonance frequency at near infra-red region of the spectrum can be detected and imaged in vivo using laser optoacoustic imaging system.

AB - The development of gold nanoparticles for molecular optoacoustic imaging is a very promising area of research and development. Enhancement of optoacoustic imaging for molecular detection of tumors requires the engineering of nanoparticles with geometrical and molecular features that can enhance selective targeting of malignant cells while optimizing the sensitivity of optoacoustic detection. In this article, cylindrical gold nanoparticles (i.e. gold nanorods) were fabricated with a plasmon resonance frequency in the near infra-red region of the spectrum, where deep irradiation of tissue is possible using an Alexandrite laser. Gold nanorods (Au-NRs) were functionalized by covalent attachment of Poly(ethylene glycol) to enhance their biocompatibility. These particles were further functionalized with the aim of targeting breast cancer cells using monoclonal antibodies that binds to Her2/neu receptors, which are over expressed on the surface of breast cancer cells. A custom Laser Optoacoustic Imaging System (LOIS) was designed and employed to image nanoparticle-targeted cancer cells in a phantom and PEGylated Au-NRs that were injected subcutaneously into a nude mouse. The results of our experiments show that functionalized Au-NRs with a plasmon resonance frequency at near infra-red region of the spectrum can be detected and imaged in vivo using laser optoacoustic imaging system.

UR - http://www.scopus.com/inward/record.url?scp=34247353806&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34247353806&partnerID=8YFLogxK

U2 - 10.1117/12.716380

DO - 10.1117/12.716380

M3 - Conference contribution

AN - SCOPUS:34247353806

SN - 081946550X

SN - 9780819465504

VL - 6437

BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

ER -