Fungal infections in the neonatal intensive care unit

Judith L. Rowen

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Fungal pathogens, primarily Candida, cause approximately 9 percent of all late-onset infections in the neonatal intensive care unit. Candida can be acquired both vertically and horizontally, so disease in the neonate is a mixture of nosocomially and perinatally acquired infection. Systemic candidiasis predominantly affects the most immature infants with more severe underlying disease. The spectrum of diseases caused by Candida ranges from uncomplicated fungemia to multiorgan dissemination; some unusual manifestations include invasive fungal dermatitis, spontaneous intestinal perforation, and brain abscesses. Although Candida is the predominant fungal pathogen in the nursery, other organisms are implicated sporadically. Catheter-associated sepsis caused by Malassezia is seen occasionally in neonates receiving lipid infusions. Filamentous fungi, both Aspergillus and zygomycetes, cause predominantly cutaneous or gastrointestinal tract infections, often associated with breaches in the mucocutaneous barrier. Knowledge of the epidemiology and clinical presentation of fungal infections in these infants is growing, but more research is needed.

Original languageEnglish (US)
Pages (from-to)107-114
Number of pages8
JournalSeminars in Pediatric Infectious Diseases
Volume12
Issue number2
DOIs
StatePublished - 2001

Fingerprint

Mycoses
Neonatal Intensive Care Units
Candida
Infection
Newborn Infant
Fungemia
Malassezia
Intestinal Perforation
Brain Abscess
Nurseries
Dermatitis
Aspergillus
Gastrointestinal Tract
Sepsis
Epidemiology
Fungi
Catheters
Lipids
Skin
Research

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)

Cite this

Fungal infections in the neonatal intensive care unit. / Rowen, Judith L.

In: Seminars in Pediatric Infectious Diseases, Vol. 12, No. 2, 2001, p. 107-114.

Research output: Contribution to journalArticle

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