Future directions in regional treatment strategies for melanoma and sarcoma

G. M. Beasley, M. I. Ross, D. S. Tyler

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Hyperthermic isolated limb perfusion (HILP) with melphalan and more recently isolated limb infusion (ILI) with melphalan +/- dactinomycin are common treatment modalities for both in-transit melanoma of the extremity and advanced extremity sarcoma. In order to further optimize treatment, future research should focus on selection of appropriate patients, verification of a technique that produces consistent results while maintaining acceptable toxicity, and development of novel strategies and agents. Development of these novel agents and strategies has potential to not only improve the efficacy of regional chemotherapy but may also help guide future strategies for systemic treatment.

Original languageEnglish (US)
Pages (from-to)301-309
Number of pages9
JournalInternational Journal of Hyperthermia
Issue number3
StatePublished - May 2008
Externally publishedYes


  • Melanoma
  • Regional chemotherapy

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Cancer Research


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