GABAergic vesicle-containing dendrites and spines: A critical element in processing sensory input in the monkey dorsal horn

Susan M. Carlton, Elizabeth S. Hayes

    Research output: Contribution to journalArticle

    25 Scopus citations

    Abstract

    Antibodies directed against γ-aminobutyric acid (GABA) were used to immunostain monkey lumbar spinal cord. In laminae I and II, ultrastructural analysis demonstrated GABA-immunoreactive (-IR) vesicle-containing dendrites as well as the more commonly emphasized immunoreactive cell bodies and terminals. Spines were a consistent feature of these dendrites, and some of the spines contained synaptic vesicles. GABA-IR dendrites were observed postsynaptic to large glomerular-type terminals, small-diameter axon terminals and other vesicle-containing dendrites. They were presynaptic to dendritic shafts and spines. These data suggest that GABA-IR dendrites and dendritic spines may play an important role not only as receptive elements but also provide a means for transferring information from neuron to neuron.

    Original languageEnglish (US)
    Pages (from-to)40-42
    Number of pages3
    JournalNeuroscience Letters
    Volume121
    Issue number1-2
    DOIs
    StatePublished - Jan 2 1991

    Keywords

    • Dendritic spine
    • Primate
    • Spinal cord
    • Vesicle-containing dendrite
    • γ-Aminobutyric acid

    ASJC Scopus subject areas

    • Neuroscience(all)

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