GABAergic vesicle-containing dendrites and spines: A critical element in processing sensory input in the monkey dorsal horn

Susan M. Carlton, Elizabeth S. Hayes

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Antibodies directed against γ-aminobutyric acid (GABA) were used to immunostain monkey lumbar spinal cord. In laminae I and II, ultrastructural analysis demonstrated GABA-immunoreactive (-IR) vesicle-containing dendrites as well as the more commonly emphasized immunoreactive cell bodies and terminals. Spines were a consistent feature of these dendrites, and some of the spines contained synaptic vesicles. GABA-IR dendrites were observed postsynaptic to large glomerular-type terminals, small-diameter axon terminals and other vesicle-containing dendrites. They were presynaptic to dendritic shafts and spines. These data suggest that GABA-IR dendrites and dendritic spines may play an important role not only as receptive elements but also provide a means for transferring information from neuron to neuron.

Original languageEnglish (US)
Pages (from-to)40-42
Number of pages3
JournalNeuroscience Letters
Volume121
Issue number1-2
DOIs
StatePublished - Jan 2 1991
Externally publishedYes

Keywords

  • Dendritic spine
  • Primate
  • Spinal cord
  • Vesicle-containing dendrite
  • γ-Aminobutyric acid

ASJC Scopus subject areas

  • Neuroscience(all)

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