GABAergic vesicle-containing dendrites and spines: A critical element in processing sensory input in the monkey dorsal horn

Susan M. Carlton; Elizabeth S. Hayes

doi:10.1016/0304-3940(91)90644-9

GABAergic vesicle-containing dendrites and spines: A critical element in processing sensory input in the monkey dorsal horn

Susan M. Carlton
, Elizabeth S. Hayes

Neurobiology

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Antibodies directed against γ-aminobutyric acid (GABA) were used to immunostain monkey lumbar spinal cord. In laminae I and II, ultrastructural analysis demonstrated GABA-immunoreactive (-IR) vesicle-containing dendrites as well as the more commonly emphasized immunoreactive cell bodies and terminals. Spines were a consistent feature of these dendrites, and some of the spines contained synaptic vesicles. GABA-IR dendrites were observed postsynaptic to large glomerular-type terminals, small-diameter axon terminals and other vesicle-containing dendrites. They were presynaptic to dendritic shafts and spines. These data suggest that GABA-IR dendrites and dendritic spines may play an important role not only as receptive elements but also provide a means for transferring information from neuron to neuron.

Original language	English (US)
Pages (from-to)	40-42
Number of pages	3
Journal	Neuroscience Letters
Volume	121
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3940(91)90644-9
State	Published - Jan 2 1991

Keywords

Dendritic spine
Primate
Spinal cord
Vesicle-containing dendrite
γ-Aminobutyric acid

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(91)90644-9

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title = "GABAergic vesicle-containing dendrites and spines: A critical element in processing sensory input in the monkey dorsal horn",

abstract = "Antibodies directed against γ-aminobutyric acid (GABA) were used to immunostain monkey lumbar spinal cord. In laminae I and II, ultrastructural analysis demonstrated GABA-immunoreactive (-IR) vesicle-containing dendrites as well as the more commonly emphasized immunoreactive cell bodies and terminals. Spines were a consistent feature of these dendrites, and some of the spines contained synaptic vesicles. GABA-IR dendrites were observed postsynaptic to large glomerular-type terminals, small-diameter axon terminals and other vesicle-containing dendrites. They were presynaptic to dendritic shafts and spines. These data suggest that GABA-IR dendrites and dendritic spines may play an important role not only as receptive elements but also provide a means for transferring information from neuron to neuron.",

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T1 - GABAergic vesicle-containing dendrites and spines

T2 - A critical element in processing sensory input in the monkey dorsal horn

AU - Carlton, Susan M.

AU - Hayes, Elizabeth S.

PY - 1991/1/2

Y1 - 1991/1/2

N2 - Antibodies directed against γ-aminobutyric acid (GABA) were used to immunostain monkey lumbar spinal cord. In laminae I and II, ultrastructural analysis demonstrated GABA-immunoreactive (-IR) vesicle-containing dendrites as well as the more commonly emphasized immunoreactive cell bodies and terminals. Spines were a consistent feature of these dendrites, and some of the spines contained synaptic vesicles. GABA-IR dendrites were observed postsynaptic to large glomerular-type terminals, small-diameter axon terminals and other vesicle-containing dendrites. They were presynaptic to dendritic shafts and spines. These data suggest that GABA-IR dendrites and dendritic spines may play an important role not only as receptive elements but also provide a means for transferring information from neuron to neuron.

AB - Antibodies directed against γ-aminobutyric acid (GABA) were used to immunostain monkey lumbar spinal cord. In laminae I and II, ultrastructural analysis demonstrated GABA-immunoreactive (-IR) vesicle-containing dendrites as well as the more commonly emphasized immunoreactive cell bodies and terminals. Spines were a consistent feature of these dendrites, and some of the spines contained synaptic vesicles. GABA-IR dendrites were observed postsynaptic to large glomerular-type terminals, small-diameter axon terminals and other vesicle-containing dendrites. They were presynaptic to dendritic shafts and spines. These data suggest that GABA-IR dendrites and dendritic spines may play an important role not only as receptive elements but also provide a means for transferring information from neuron to neuron.

KW - Dendritic spine

KW - Primate

KW - Spinal cord

KW - Vesicle-containing dendrite

KW - γ-Aminobutyric acid

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GABAergic vesicle-containing dendrites and spines: A critical element in processing sensory input in the monkey dorsal horn

Abstract

Keywords

ASJC Scopus subject areas

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