Galactose ingestion increases vascular permeability and collagen solubility in normal male rats

K. Chang, M. Tomlinson, J. R. Jeffrey, Ronald Tilton, W. R. Sherman, K. E. Ackermann, R. A. Berger, T. J. Cicero, C. Kilo, J. R. Williamson

Research output: Contribution to journalArticle

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Abstract

In view of the similarity of cataracts and neuropathy in galactose-fed and diabetic rats, the present experiments were undertaken to determine whether consumption of galactose-enriched diet (10, 25, or 50% by weight) also increases collagen crosslinking and permeation of vessels by 125I-albumin analagous to that observed in diabetic rats. The observations in these experiments: (a) demonstrate that consumption of galactose-enriched diets for 3 wk selectively increases 125I-albumin permeation of the same vascular beds affected in diabetic rats and by diabetic vascular disease in humans (i.e., the aorta and vessels in the eye, kidney, sciatic nerve, and new tissue formed in the diabetic milieu); (b) demonstrate that the susceptibility of the vasculature to aldose reductase-linked injury (increased permeability) varies greatly in different tissues; (3) indicate that collagen solubility (crosslinking) changes in galactose-fed rats differ sharply from those in diabetic rats; and (d) provide new evidence that consumption of galactose-enriched diets induces a hypogonadal state in male rats.

Original languageEnglish (US)
Pages (from-to)367-373
Number of pages7
JournalJournal of Clinical Investigation
Volume79
Issue number2
StatePublished - 1987
Externally publishedYes

Fingerprint

Capillary Permeability
Galactose
Solubility
Collagen
Eating
Diet
Albumins
Diabetic Angiopathies
Nerve Tissue
Aldehyde Reductase
Sciatic Nerve
Cataract
Blood Vessels
Aorta
Permeability
Kidney
Weights and Measures
Wounds and Injuries

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Chang, K., Tomlinson, M., Jeffrey, J. R., Tilton, R., Sherman, W. R., Ackermann, K. E., ... Williamson, J. R. (1987). Galactose ingestion increases vascular permeability and collagen solubility in normal male rats. Journal of Clinical Investigation, 79(2), 367-373.

Galactose ingestion increases vascular permeability and collagen solubility in normal male rats. / Chang, K.; Tomlinson, M.; Jeffrey, J. R.; Tilton, Ronald; Sherman, W. R.; Ackermann, K. E.; Berger, R. A.; Cicero, T. J.; Kilo, C.; Williamson, J. R.

In: Journal of Clinical Investigation, Vol. 79, No. 2, 1987, p. 367-373.

Research output: Contribution to journalArticle

Chang, K, Tomlinson, M, Jeffrey, JR, Tilton, R, Sherman, WR, Ackermann, KE, Berger, RA, Cicero, TJ, Kilo, C & Williamson, JR 1987, 'Galactose ingestion increases vascular permeability and collagen solubility in normal male rats', Journal of Clinical Investigation, vol. 79, no. 2, pp. 367-373.
Chang K, Tomlinson M, Jeffrey JR, Tilton R, Sherman WR, Ackermann KE et al. Galactose ingestion increases vascular permeability and collagen solubility in normal male rats. Journal of Clinical Investigation. 1987;79(2):367-373.
Chang, K. ; Tomlinson, M. ; Jeffrey, J. R. ; Tilton, Ronald ; Sherman, W. R. ; Ackermann, K. E. ; Berger, R. A. ; Cicero, T. J. ; Kilo, C. ; Williamson, J. R. / Galactose ingestion increases vascular permeability and collagen solubility in normal male rats. In: Journal of Clinical Investigation. 1987 ; Vol. 79, No. 2. pp. 367-373.
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AU - Berger, R. A.

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AU - Kilo, C.

AU - Williamson, J. R.

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