Gallstone composition: Are children different?

Mark D. Stringer, Donald R. Taylor, Roger D. Soloway

Research output: Contribution to journalArticle

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Abstract

During a 5-year period (1997-2002) 20 consecutive children (11 boys; median age, 8 years; range, 0.3-13.9 years) underwent cholecystectomy for cholelithiasis at a regional pediatric surgical center. Multiple stones were present in 16 patients (80%). All stones were collected prospectively. Composition studies were performed after grinding an aliquot of stone and examining a layer of crushed powder by Fourier transform infrared microspectroscopy. The relative proportions of each major stone component were assessed: cholesterol, protein and calcium salts of bilirubin, fatty acids, carbonate, and hydroxyapatite. Of the 20 children, 10 had black pigment stones, 2 had cholesterol stones, 1 had brown pigment stones, and 7 had calcium carbonate stones; the latter are exceptionally rare in adults. The composition of pediatric gallstones in this series differs from that found in adults.

Original languageEnglish (US)
Pages (from-to)435-440
Number of pages6
JournalJournal of Pediatrics
Volume142
Issue number4
DOIs
StatePublished - Apr 1 2003

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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Stringer, M. D., Taylor, D. R., & Soloway, R. D. (2003). Gallstone composition: Are children different? Journal of Pediatrics, 142(4), 435-440. https://doi.org/10.1067/mpd.2003.159