Gamna-Gandy bodies in fine-needle aspiration from abdominal splenosis: A clue to underlying portal hypertension

Evgeniya A. Angelova, Arya Bagherpour, Vicki J Schnadig, Jing He

Research output: Contribution to journalArticlepeer-review

Abstract

A 40-year-old woman presented with abdominal pain and jaundice. Past medical history was significant only for splenectomy following a motor vehicle accident. Owing to presence of multiple peritoneal nodules on computerized tomography (CT) and elevated serum CA-125, ovarian peritoneal carcinomatosis was suspected. Ultrasound-guided fine-needle aspiration (FNA) revealed presence of abundant hemosiderin, leukocytes, endothelial cells, and fungal hypha-like structures. No evidence of neoplasia was found. Findings were consistent with Gamna-Gandy bodies (GGBS) within splenic tissue. Based on history of splenectomy and FNA findings, a diagnosis of abdominal splenosis with presence of GGBS was made. Workup for hepatic cirrhosis and portal hypertension was recommended. Liver biopsy confirmed presence of cirrhosis. To our knowledge, this is the first report of GGBS identified within abdominal splenosis. It is important for pathologists to be able to recognize GGBS and to be aware of their relationship to portal hypertension and other conditions associated with severe vascular congestion or hemorrhage. History and pathogenesis of GGBS, their diagnostic morphologic features and a review of cases of GGBS diagnosed via cytology are given.

Original languageEnglish (US)
Pages (from-to)670-674
Number of pages5
JournalDiagnostic cytopathology
Volume48
Issue number7
DOIs
StatePublished - Jul 1 2020

Keywords

  • Gamna-Gandy
  • fine-needle aspiration
  • portal hypertension
  • splenosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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