Structure and quantities of gangliosides in skin fibroblasts derived from normal children and patients with several hereditary diseases are studied. Mono and disialohematosides are the only gangliosides found. There was a 6-fold increase in lipid-bound neuraminic acid in the Hurler variant and 2.3-fold increase in Krabbe's diesease as compared to the highest normal cells grown under the same conditions. The addition of calf-serum to the growth medium caused a substantial increase in the hematosides and also the occurrence of N-glycoloylneuraminic acid besides N-acetylneuraminic acid.
|Original language||English (US)|
|Number of pages||9|
|Journal||Hoppe-Seyler's Zeitschrift fur Physiologische Chemie|
|State||Published - 1971|
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