Gap junctions in cells of the immune system: Structure, regulation and possible functional roles

J. C. Sáez, M. C. Brañes, L. A. Corvalán, Eliseo Eugenin, H. González, A. D. Martínez, F. Palisson

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Gap junction channels are sites of cytoplasmic communication between contacting cells. In vertebrates, they consist of protein subunits denoted connexins (Cxs) which are encoded by a gene family. According to their Cx composition, gap junction channels show different gating and permeability properties that define which ions and small molecules permeate them. Differences in Cx primary sequences suggest that channels composed of different Cxs are regulated differentially by intracellular pathways under specific physiological conditions. Functional roles of gap junction channels could be defined by the relative importance of permeant substances, resulting in coordination of electrical and/or metabolic cellular responses. Cells of the native and specific immune systems establish transient homo- and heterocellular contacts at various steps of the immune response. Morphological and functional studies reported during the last three decades have revealed that many intercellular contacts between cells in the immune response present gap junctions or "gap junction-like" structures. Partial characterization of the molecular composition of some of these plasma membrane structures and regulatory mechanisms that control them have been published recently. Studies designed to elucidate their physiological roles suggest that they might permit coordination of cellular events which favor the effective and timely response of the immune system.

Original languageEnglish (US)
Pages (from-to)447-455
Number of pages9
JournalBrazilian Journal of Medical and Biological Research
Volume33
Issue number4
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

Fingerprint

Connexins
Immune system
Gap Junctions
Immune System
Membrane structures
Protein Subunits
Cell membranes
Chemical analysis
Genes
Ions
Molecules
Communication
Vertebrates
Permeability
Cell Membrane

Keywords

  • Cell contacts
  • Connexins
  • Gap junctions
  • Inflammatory response
  • Native immune response
  • Specific immune response

ASJC Scopus subject areas

  • Biophysics
  • Neuroscience(all)
  • Biochemistry
  • Physiology
  • Immunology
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Cell Biology

Cite this

Gap junctions in cells of the immune system : Structure, regulation and possible functional roles. / Sáez, J. C.; Brañes, M. C.; Corvalán, L. A.; Eugenin, Eliseo; González, H.; Martínez, A. D.; Palisson, F.

In: Brazilian Journal of Medical and Biological Research, Vol. 33, No. 4, 01.01.2000, p. 447-455.

Research output: Contribution to journalArticle

Sáez, J. C. ; Brañes, M. C. ; Corvalán, L. A. ; Eugenin, Eliseo ; González, H. ; Martínez, A. D. ; Palisson, F. / Gap junctions in cells of the immune system : Structure, regulation and possible functional roles. In: Brazilian Journal of Medical and Biological Research. 2000 ; Vol. 33, No. 4. pp. 447-455.
@article{fa78f2809e184d0cb87fce960cdf53c0,
title = "Gap junctions in cells of the immune system: Structure, regulation and possible functional roles",
abstract = "Gap junction channels are sites of cytoplasmic communication between contacting cells. In vertebrates, they consist of protein subunits denoted connexins (Cxs) which are encoded by a gene family. According to their Cx composition, gap junction channels show different gating and permeability properties that define which ions and small molecules permeate them. Differences in Cx primary sequences suggest that channels composed of different Cxs are regulated differentially by intracellular pathways under specific physiological conditions. Functional roles of gap junction channels could be defined by the relative importance of permeant substances, resulting in coordination of electrical and/or metabolic cellular responses. Cells of the native and specific immune systems establish transient homo- and heterocellular contacts at various steps of the immune response. Morphological and functional studies reported during the last three decades have revealed that many intercellular contacts between cells in the immune response present gap junctions or {"}gap junction-like{"} structures. Partial characterization of the molecular composition of some of these plasma membrane structures and regulatory mechanisms that control them have been published recently. Studies designed to elucidate their physiological roles suggest that they might permit coordination of cellular events which favor the effective and timely response of the immune system.",
keywords = "Cell contacts, Connexins, Gap junctions, Inflammatory response, Native immune response, Specific immune response",
author = "S{\'a}ez, {J. C.} and Bra{\~n}es, {M. C.} and Corval{\'a}n, {L. A.} and Eliseo Eugenin and H. Gonz{\'a}lez and Mart{\'i}nez, {A. D.} and F. Palisson",
year = "2000",
month = "1",
day = "1",
doi = "10.1590/S0100-879X2000000400011",
language = "English (US)",
volume = "33",
pages = "447--455",
journal = "Brazilian Journal of Medical and Biological Research",
issn = "0100-879X",
publisher = "Associacao Brasileira de Divulgacao Cientifica",
number = "4",

}

TY - JOUR

T1 - Gap junctions in cells of the immune system

T2 - Structure, regulation and possible functional roles

AU - Sáez, J. C.

AU - Brañes, M. C.

AU - Corvalán, L. A.

AU - Eugenin, Eliseo

AU - González, H.

AU - Martínez, A. D.

AU - Palisson, F.

PY - 2000/1/1

Y1 - 2000/1/1

N2 - Gap junction channels are sites of cytoplasmic communication between contacting cells. In vertebrates, they consist of protein subunits denoted connexins (Cxs) which are encoded by a gene family. According to their Cx composition, gap junction channels show different gating and permeability properties that define which ions and small molecules permeate them. Differences in Cx primary sequences suggest that channels composed of different Cxs are regulated differentially by intracellular pathways under specific physiological conditions. Functional roles of gap junction channels could be defined by the relative importance of permeant substances, resulting in coordination of electrical and/or metabolic cellular responses. Cells of the native and specific immune systems establish transient homo- and heterocellular contacts at various steps of the immune response. Morphological and functional studies reported during the last three decades have revealed that many intercellular contacts between cells in the immune response present gap junctions or "gap junction-like" structures. Partial characterization of the molecular composition of some of these plasma membrane structures and regulatory mechanisms that control them have been published recently. Studies designed to elucidate their physiological roles suggest that they might permit coordination of cellular events which favor the effective and timely response of the immune system.

AB - Gap junction channels are sites of cytoplasmic communication between contacting cells. In vertebrates, they consist of protein subunits denoted connexins (Cxs) which are encoded by a gene family. According to their Cx composition, gap junction channels show different gating and permeability properties that define which ions and small molecules permeate them. Differences in Cx primary sequences suggest that channels composed of different Cxs are regulated differentially by intracellular pathways under specific physiological conditions. Functional roles of gap junction channels could be defined by the relative importance of permeant substances, resulting in coordination of electrical and/or metabolic cellular responses. Cells of the native and specific immune systems establish transient homo- and heterocellular contacts at various steps of the immune response. Morphological and functional studies reported during the last three decades have revealed that many intercellular contacts between cells in the immune response present gap junctions or "gap junction-like" structures. Partial characterization of the molecular composition of some of these plasma membrane structures and regulatory mechanisms that control them have been published recently. Studies designed to elucidate their physiological roles suggest that they might permit coordination of cellular events which favor the effective and timely response of the immune system.

KW - Cell contacts

KW - Connexins

KW - Gap junctions

KW - Inflammatory response

KW - Native immune response

KW - Specific immune response

UR - http://www.scopus.com/inward/record.url?scp=0034170097&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034170097&partnerID=8YFLogxK

U2 - 10.1590/S0100-879X2000000400011

DO - 10.1590/S0100-879X2000000400011

M3 - Article

C2 - 10775310

AN - SCOPUS:0034170097

VL - 33

SP - 447

EP - 455

JO - Brazilian Journal of Medical and Biological Research

JF - Brazilian Journal of Medical and Biological Research

SN - 0100-879X

IS - 4

ER -