Garrotes, springs, ratchets, and whips: Putting dynamin models to the test

Sanja Sever, Hanna Damke, Sandra L. Schmid

Research output: Contribution to journalReview articlepeer-review

185 Scopus citations


The GTPase dynamin is essential for clathrin-mediated endocytosis. Numerous new and exciting discoveries regarding dynamin function in vivo and in vitro have led to various models in which dynamin functions directly in membrane fission and the release of clathrin-coated vesicles from the plasma membrane. This would make dynamin unique among GTPases in its ability to act as a mechanochemical enzyme. Here we review the various models and their supporting data. We then discuss new findings that raise doubts as to whether dynamin breaks the paradigm that governs regulatory GTPases.

Original languageEnglish (US)
Pages (from-to)385-392
Number of pages8
Issue number5
StatePublished - May 2000
Externally publishedYes

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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