TY - JOUR
T1 - Gaseotransmitters
T2 - New frontiers for translational science
AU - Szabo, Csaba
PY - 2010/11/24
Y1 - 2010/11/24
N2 - Translational research on endogenous gaseous mediators - nitric oxide, carbon monoxide, and hydrogen sulfide - has exploded over the past decade. Drugs that modulate either the gaseous mediators themselves or their related intracellular signaling pathways are already in use in the clinics, and still more are being tested in preclinical models and clinical trials. Discussed here are the chemical and pharmacological properties that present challenges for the translation of these potentially toxic molecules.
AB - Translational research on endogenous gaseous mediators - nitric oxide, carbon monoxide, and hydrogen sulfide - has exploded over the past decade. Drugs that modulate either the gaseous mediators themselves or their related intracellular signaling pathways are already in use in the clinics, and still more are being tested in preclinical models and clinical trials. Discussed here are the chemical and pharmacological properties that present challenges for the translation of these potentially toxic molecules.
UR - http://www.scopus.com/inward/record.url?scp=78649439251&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78649439251&partnerID=8YFLogxK
U2 - 10.1126/scitranslmed.3000721
DO - 10.1126/scitranslmed.3000721
M3 - Review article
C2 - 21106939
AN - SCOPUS:78649439251
SN - 1946-6234
VL - 2
JO - Science Translational Medicine
JF - Science Translational Medicine
IS - 59
M1 - 59ps54
ER -