Gaseotransmitters: New frontiers for translational science

Csaba Szabo

Research output: Contribution to journalReview articlepeer-review

93 Scopus citations

Abstract

Translational research on endogenous gaseous mediators - nitric oxide, carbon monoxide, and hydrogen sulfide - has exploded over the past decade. Drugs that modulate either the gaseous mediators themselves or their related intracellular signaling pathways are already in use in the clinics, and still more are being tested in preclinical models and clinical trials. Discussed here are the chemical and pharmacological properties that present challenges for the translation of these potentially toxic molecules.

Original languageEnglish (US)
Article number59ps54
JournalScience Translational Medicine
Volume2
Issue number59
DOIs
StatePublished - Nov 24 2010
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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