Gasotransmitters in cancer: From pathophysiology to experimental therapy

Csaba Szabo

    Research output: Contribution to journalReview article

    185 Scopus citations

    Abstract

    The three endogenous gaseous transmitters-nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H 2 S)-regulate a number of key biological functions. Emerging data have revealed several new mechanisms for each of these three gasotransmitters in tumour biology. It is now appreciated that they show bimodal pharmacological character in cancer, in that not only the inhibition of their biosynthesis but also elevation of their concentration beyond a certain threshold can exert anticancer effects. This Review discusses the role of each gasotransmitter in cancer and the effects of pharmacological agents-some of which are in early-stage clinical studies-that modulate the levels of each gasotransmitter. A clearer understanding of the pharmacological character of these three gases and the mechanisms underlying their biological effects is expected to guide further clinical translation.

    Original languageEnglish (US)
    Pages (from-to)185-203
    Number of pages19
    JournalNature Reviews Drug Discovery
    Volume15
    Issue number3
    DOIs
    StatePublished - Mar 1 2016

    ASJC Scopus subject areas

    • Pharmacology
    • Drug Discovery

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