Gastrin as a trophic hormone

L. R. Johnson, R. Arnold, G. Delle Fave, R. Hakanson, J. Ishizuka, C. M. Townsend

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Gastrin acts as a trophic hormone and hypergastrinaemia is associated with gastric mucosal hyperplasia. The circulating levels of gastrin are controlled by several mechanisms such as intragastric acid and nutrients, endocrine and paracrine peptide mediators and nerves. In clinical practice, most of the hypergastrinaemia conditions are due to an altered regulation of gastric acid secretion or to long-term acid suppression treatment. Hypergastrinaemia conditions are linked to enterochromaffin-like (ECS) cells and carcinoids. It is also possible that hypergastrinaemia may act indirectly on the carcinogenesis of gastric and colon cancers or may act trophically on these cancers if they possess gastrin receptors.

Original languageEnglish (US)
Pages (from-to)55-73
Number of pages19
JournalGastroenterology International
Volume7
Issue number2
StatePublished - Jan 1 1994
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology

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    Johnson, L. R., Arnold, R., Delle Fave, G., Hakanson, R., Ishizuka, J., & Townsend, C. M. (1994). Gastrin as a trophic hormone. Gastroenterology International, 7(2), 55-73.