TY - JOUR
T1 - Gastrin-releasing peptide as a molecular target for inflammatory diseases
T2 - an update.
AU - Petronilho, Fabricia
AU - Danielski, Lucineia Gainski
AU - Roesler, Rafael
AU - Schwartsmann, Gilberto
AU - Dal-Pizzol, Felipe
PY - 2013/6
Y1 - 2013/6
N2 - Gastrin-releasing peptide (GRP) is a neuropeptide that acts through G protein coupled receptors and is involved in signal transmission in both the central and peripheral nervous systems. Its receptor, gastrin-releasing peptide receptor (GRPR), is expressed by various cell types, and it is overexpressed in cancer cells. In recent years, studies have suggested the relationship of GRP and inflammatory diseases. RC-3095, a selective GRPR antagonist, was found to have antiinflammatory properties in models of arthritis, gastritis, uveitis and sepsis. Furthermore, GRP mediates air pollutioninduced airway hyperreactivity and airway inflammation in mice. In conclusion, GRP and its receptor are relevant to the inflammatory response, being a potential therapeutic target several diseases are related to inflammation.
AB - Gastrin-releasing peptide (GRP) is a neuropeptide that acts through G protein coupled receptors and is involved in signal transmission in both the central and peripheral nervous systems. Its receptor, gastrin-releasing peptide receptor (GRPR), is expressed by various cell types, and it is overexpressed in cancer cells. In recent years, studies have suggested the relationship of GRP and inflammatory diseases. RC-3095, a selective GRPR antagonist, was found to have antiinflammatory properties in models of arthritis, gastritis, uveitis and sepsis. Furthermore, GRP mediates air pollutioninduced airway hyperreactivity and airway inflammation in mice. In conclusion, GRP and its receptor are relevant to the inflammatory response, being a potential therapeutic target several diseases are related to inflammation.
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U2 - 10.2174/1871528111312030003
DO - 10.2174/1871528111312030003
M3 - Review article
C2 - 23621446
AN - SCOPUS:84897120256
SN - 1871-5281
VL - 12
SP - 172
EP - 177
JO - Inflammation & allergy drug targets
JF - Inflammation & allergy drug targets
IS - 3
ER -