Gastroduodenal motility

S. K. Sarna, M. F. Otterson

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Significant advances were reported in several areas of gastroduodenal motility during the past 12 months. The complexity and multifactorial control of gastric emptying rate was highlighted. It seems that simultaneous analysis of the spatial and temporal characteristics of gastro-pyloro-duodenal contractions is important in fully understanding the mechanisms of regulation of gastric emptying. Cholecystokinin may play an important role in the afferent sensory pathway to inhibit gastric emptying by neurohormonal feedback from the duodenum. Very little progress was made in elucidating the etiology of dyspepsia. However, it seems that cisapride may be effective in relieving symptoms of dyspepsia at least in some patients. Erythromycin remains a potential gastro-prokinetic agent. However, like other prokinetic agents, it may not be effective in all patients with gastric stasis and the patients may become refractory after long-term use. The method of monitoring gastric function by cutaneous electrogastrogram is noninvasive and convenient, but the information it can provide is very limited. This raises serious questions about its potential as a diagnostic tool. Finally, absence of nitric oxide synthase in the enteric nerves of the pyloric circular muscle may be a factor in infantile hypertrophic pyloric stenosis.

Original languageEnglish (US)
Pages (from-to)922-929
Number of pages8
JournalCurrent Opinion in Gastroenterology
Volume9
Issue number6
StatePublished - 1993
Externally publishedYes

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Gastric Emptying
Dyspepsia
Spatio-Temporal Analysis
Cisapride
Gastroparesis
Afferent Pathways
Cholecystokinin
Erythromycin
Duodenum
Nitric Oxide Synthase
Stomach
Muscles
Skin

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Sarna, S. K., & Otterson, M. F. (1993). Gastroduodenal motility. Current Opinion in Gastroenterology, 9(6), 922-929.

Gastroduodenal motility. / Sarna, S. K.; Otterson, M. F.

In: Current Opinion in Gastroenterology, Vol. 9, No. 6, 1993, p. 922-929.

Research output: Contribution to journalArticle

Sarna, SK & Otterson, MF 1993, 'Gastroduodenal motility', Current Opinion in Gastroenterology, vol. 9, no. 6, pp. 922-929.
Sarna SK, Otterson MF. Gastroduodenal motility. Current Opinion in Gastroenterology. 1993;9(6):922-929.
Sarna, S. K. ; Otterson, M. F. / Gastroduodenal motility. In: Current Opinion in Gastroenterology. 1993 ; Vol. 9, No. 6. pp. 922-929.
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