Gastrointestinal carcinoids: Characterization by site of origin and hormone production

Mark W. Onaitis, Paul M. Kirshbom, Thomas Z. Hayward, Frank J. Quayle, Jerome M. Feldman, Hilliard F. Seigler, Douglas Tyler

Research output: Contribution to journalArticle

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Abstract

Objective: To describe a large series of patients with carcinoid tumors in terms of presenting symptoms, hormonal data, stage at diagnosis, pathologic features, and survival. Summary Background Data: Published series have described significant prognostic features of carcinoid tumors as site of origin, age, sex, stage at diagnosis, presence of high hormone levels, and increased T stage. Of these, stage at diagnosis and T stage seem to emerge most often as independent predictors of survival in multivariate analyses. Of carcinoid tumors, those arising from a midgut location have higher levels of serotonin and serotonin breakdown products, as well as more frequent metastatic disease at presentation, than those arising from either foregut or hindgut locations. Methods: A prospective database of carcinoid patients seen at Duke University Medical Center was kept from 1970 to the present. Retrospective medical record review was performed on this database to record presenting symptoms, hormonal data, pathologic features, and survival. Statistical methods included analysis of variance, Kaplan-Meier analysis, and Mantel-Cox proportional hazard survival analysis, with P < .05 considered significant for all tests. Results: Carcinoids arising in different locations had different presentations: rectal carcinoids presented significantly more often with gastrointestinal bleeding, and midgut carcinoids presented significantly more often with flushing, diarrhea, and the carcinoid syndrome. Patients with midgut tumors had significantly higher levels of serotonin and serotonin breakdown products, corresponding to higher metastatic tumor burdens. Although age, stage, region of origin, and urinary level of 5-hydroxyin-doleacetic acid predicted survival by univariate analysis, only the latter three were independent predictors of survival by multivariate analysis. Of the patients with metastatic disease at diagnosis, those with midgut tumors had better survival than those with foregut or hindgut tumors. Conclusions: Although region of origin is certainly an important factor in determination of prognosis, stage of disease at presentation is more predictive of survival. Pancreatic and midgut carcinoids are metastatic at diagnosis more often than those arising in other locations, leading to a worse overall prognosis. Among patients with distant metastases, patients with midgut primary tumors have improved survival despite increased hormone production compared with patients with tumors arising in other primary sites.

Original languageEnglish (US)
Pages (from-to)549-556
Number of pages8
JournalAnnals of Surgery
Volume232
Issue number4
DOIs
StatePublished - 2000
Externally publishedYes

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Carcinoid Tumor
Hormones
Survival
Serotonin
Survival Analysis
Neoplasms
Multivariate Analysis
Databases
Kaplan-Meier Estimate
Tumor Burden
Medical Records
Diarrhea
Analysis of Variance
Hemorrhage
Neoplasm Metastasis
Acids

ASJC Scopus subject areas

  • Surgery

Cite this

Onaitis, M. W., Kirshbom, P. M., Hayward, T. Z., Quayle, F. J., Feldman, J. M., Seigler, H. F., & Tyler, D. (2000). Gastrointestinal carcinoids: Characterization by site of origin and hormone production. Annals of Surgery, 232(4), 549-556. https://doi.org/10.1097/00000658-200010000-00010

Gastrointestinal carcinoids : Characterization by site of origin and hormone production. / Onaitis, Mark W.; Kirshbom, Paul M.; Hayward, Thomas Z.; Quayle, Frank J.; Feldman, Jerome M.; Seigler, Hilliard F.; Tyler, Douglas.

In: Annals of Surgery, Vol. 232, No. 4, 2000, p. 549-556.

Research output: Contribution to journalArticle

Onaitis, MW, Kirshbom, PM, Hayward, TZ, Quayle, FJ, Feldman, JM, Seigler, HF & Tyler, D 2000, 'Gastrointestinal carcinoids: Characterization by site of origin and hormone production', Annals of Surgery, vol. 232, no. 4, pp. 549-556. https://doi.org/10.1097/00000658-200010000-00010
Onaitis MW, Kirshbom PM, Hayward TZ, Quayle FJ, Feldman JM, Seigler HF et al. Gastrointestinal carcinoids: Characterization by site of origin and hormone production. Annals of Surgery. 2000;232(4):549-556. https://doi.org/10.1097/00000658-200010000-00010
Onaitis, Mark W. ; Kirshbom, Paul M. ; Hayward, Thomas Z. ; Quayle, Frank J. ; Feldman, Jerome M. ; Seigler, Hilliard F. ; Tyler, Douglas. / Gastrointestinal carcinoids : Characterization by site of origin and hormone production. In: Annals of Surgery. 2000 ; Vol. 232, No. 4. pp. 549-556.
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abstract = "Objective: To describe a large series of patients with carcinoid tumors in terms of presenting symptoms, hormonal data, stage at diagnosis, pathologic features, and survival. Summary Background Data: Published series have described significant prognostic features of carcinoid tumors as site of origin, age, sex, stage at diagnosis, presence of high hormone levels, and increased T stage. Of these, stage at diagnosis and T stage seem to emerge most often as independent predictors of survival in multivariate analyses. Of carcinoid tumors, those arising from a midgut location have higher levels of serotonin and serotonin breakdown products, as well as more frequent metastatic disease at presentation, than those arising from either foregut or hindgut locations. Methods: A prospective database of carcinoid patients seen at Duke University Medical Center was kept from 1970 to the present. Retrospective medical record review was performed on this database to record presenting symptoms, hormonal data, pathologic features, and survival. Statistical methods included analysis of variance, Kaplan-Meier analysis, and Mantel-Cox proportional hazard survival analysis, with P < .05 considered significant for all tests. Results: Carcinoids arising in different locations had different presentations: rectal carcinoids presented significantly more often with gastrointestinal bleeding, and midgut carcinoids presented significantly more often with flushing, diarrhea, and the carcinoid syndrome. Patients with midgut tumors had significantly higher levels of serotonin and serotonin breakdown products, corresponding to higher metastatic tumor burdens. Although age, stage, region of origin, and urinary level of 5-hydroxyin-doleacetic acid predicted survival by univariate analysis, only the latter three were independent predictors of survival by multivariate analysis. Of the patients with metastatic disease at diagnosis, those with midgut tumors had better survival than those with foregut or hindgut tumors. Conclusions: Although region of origin is certainly an important factor in determination of prognosis, stage of disease at presentation is more predictive of survival. Pancreatic and midgut carcinoids are metastatic at diagnosis more often than those arising in other locations, leading to a worse overall prognosis. Among patients with distant metastases, patients with midgut primary tumors have improved survival despite increased hormone production compared with patients with tumors arising in other primary sites.",
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AU - Seigler, Hilliard F.

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N2 - Objective: To describe a large series of patients with carcinoid tumors in terms of presenting symptoms, hormonal data, stage at diagnosis, pathologic features, and survival. Summary Background Data: Published series have described significant prognostic features of carcinoid tumors as site of origin, age, sex, stage at diagnosis, presence of high hormone levels, and increased T stage. Of these, stage at diagnosis and T stage seem to emerge most often as independent predictors of survival in multivariate analyses. Of carcinoid tumors, those arising from a midgut location have higher levels of serotonin and serotonin breakdown products, as well as more frequent metastatic disease at presentation, than those arising from either foregut or hindgut locations. Methods: A prospective database of carcinoid patients seen at Duke University Medical Center was kept from 1970 to the present. Retrospective medical record review was performed on this database to record presenting symptoms, hormonal data, pathologic features, and survival. Statistical methods included analysis of variance, Kaplan-Meier analysis, and Mantel-Cox proportional hazard survival analysis, with P < .05 considered significant for all tests. Results: Carcinoids arising in different locations had different presentations: rectal carcinoids presented significantly more often with gastrointestinal bleeding, and midgut carcinoids presented significantly more often with flushing, diarrhea, and the carcinoid syndrome. Patients with midgut tumors had significantly higher levels of serotonin and serotonin breakdown products, corresponding to higher metastatic tumor burdens. Although age, stage, region of origin, and urinary level of 5-hydroxyin-doleacetic acid predicted survival by univariate analysis, only the latter three were independent predictors of survival by multivariate analysis. Of the patients with metastatic disease at diagnosis, those with midgut tumors had better survival than those with foregut or hindgut tumors. Conclusions: Although region of origin is certainly an important factor in determination of prognosis, stage of disease at presentation is more predictive of survival. Pancreatic and midgut carcinoids are metastatic at diagnosis more often than those arising in other locations, leading to a worse overall prognosis. Among patients with distant metastases, patients with midgut primary tumors have improved survival despite increased hormone production compared with patients with tumors arising in other primary sites.

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