Gastrointestinal motor correlates of vomiting in the dog: Quantification and characterization as an independent phenomenon

Ivan M. Lang, Sushil K. Sarna, Robert E. Condon

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

The gastrointestinal motor correlates of vomiting were examined in 8 dogs. Each dog was chronically implanted with extramural strain gage force transducers distributed along the gastrointestinal tract. The following gastrointestinal motor responses accompanied vomiting activated spontaneously or after apomorphine administration (2.5-15 μg/kg, i.v.): (a) a retrograde peristaltic contraction (RPC), (b) a peri-RPC inhibitory period, (c) a post-RPC series of phasic contractions, and (d) a post-RPC inhibitory period. These same motor patterns occurred without the somatomotor responses associated with vomiting but sometimes with regurgitation under the following conditions: (a) spontaneously, (b) one-third of the time after low doses of apomorphine (2.5-5.0 μg/kg, i.v.), or (c) after the intragastric administration of hypertonic saline or a vinegar solution. We concluded that a set of gastrointestinal motor responses accompany vomiting and that this set of responses represents an independent phenomenon. This phenomenon was vagally mediated but only one phase, the RPC, was cholinergically mediated, Our results suggest that the vomiting center may consist of two functionally distinct parts that are activated sequentially: one controlling the gastrointestinal responses and the other the somatomotor responses.

Original languageEnglish (US)
Pages (from-to)40-47
Number of pages8
JournalGastroenterology
Volume90
Issue number1
StatePublished - 1986
Externally publishedYes

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Vomiting
Dogs
Apomorphine
Transducers
Acetic Acid
Gastrointestinal Tract

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Gastrointestinal motor correlates of vomiting in the dog : Quantification and characterization as an independent phenomenon. / Lang, Ivan M.; Sarna, Sushil K.; Condon, Robert E.

In: Gastroenterology, Vol. 90, No. 1, 1986, p. 40-47.

Research output: Contribution to journalArticle

Lang, Ivan M. ; Sarna, Sushil K. ; Condon, Robert E. / Gastrointestinal motor correlates of vomiting in the dog : Quantification and characterization as an independent phenomenon. In: Gastroenterology. 1986 ; Vol. 90, No. 1. pp. 40-47.
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