GB virus C infection and B-cell, natural killer cell, and monocyte activation markers in HIV-infected individuals

Jack T. Stapleton, Jeffrey A. Martinson, Donna Klinzman, Jinhua Xiang, Seema N. Desai, Alan Landay

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

GB virus C (GBV-C), a pan-lymphotropic flavivirus capable of persistent infection, is associated with prolonged survival and reduced T-cell activation in HIV-infected patients. GBV-C was associated with reduced CD56brt/CD16 natural killer cell and monocyte activation, and a trend toward reduced B-cell activation by measuring cell surface activation markers or HIV entry coreceptors. The GBV-C association was independent of HIV viral load. Thus, GBV-C may influence non-T-cell immune activation in individuals with HIV infection.

Original languageEnglish (US)
Pages (from-to)1829-1832
Number of pages4
JournalAIDS
Volume27
Issue number11
DOIs
StatePublished - Jul 17 2013
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Fingerprint

Dive into the research topics of 'GB virus C infection and B-cell, natural killer cell, and monocyte activation markers in HIV-infected individuals'. Together they form a unique fingerprint.

Cite this