Gender differences in basal protein kinetics in young adults

Elena Volpi, Paola Lucidi, Geremia B. Bolli, Fausto Santeusanio, Pierpaolo De Feo

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Gender affects energy expenditure and influences the relative utilization of carbohydrate and fat as fuels. However, little is known about the possible effects of gender on protein metabolism. Thus, we compared whole body and plasma (albumin and fibrinogen) protein kinetics in the basal postabsorptive state in young, untrained volunteers divided into two groups according to gender (women: n = 17; age, 24 ± 4 yr; men: n = 17; age, 25 ± 2 yr). The two groups were matched for body mass index. Protein kinetics were measured by means of L-[1-14C]leucine infusion. The leucine whole body rate of appearance, an index of proteolysis, and nonoxidative rate of disappearance, an index of protein synthesis, were similar in the two groups. However, the leucine oxidation rate was significantly lower in women compared to men (0.23 ± 0.07 vs. 0.31 ± 0.08 μnol/kg·min; P = 0.0062). Similar results were obtained when data were adjusted for estimated body composition. Albumin and fibrinogen fractional secretion rates were not different in the two groups. In conclusion, in the basal state leucine oxidation is lower in women than in men regardless of body composition. This could be one of the factors contributing to the lower metabolic rate in women.

Original languageEnglish (US)
Pages (from-to)4363-4367
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume83
Issue number12
StatePublished - 1998
Externally publishedYes

Fingerprint

Leucine
Young Adult
Kinetics
Body Composition
Fibrinogen
Proteins
Proteolysis
Oxidation
Chemical analysis
Metabolism
Serum Albumin
Energy Metabolism
Volunteers
Albumins
Body Mass Index
Research Design
Fats
Carbohydrates

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Volpi, E., Lucidi, P., Bolli, G. B., Santeusanio, F., & De Feo, P. (1998). Gender differences in basal protein kinetics in young adults. Journal of Clinical Endocrinology and Metabolism, 83(12), 4363-4367.

Gender differences in basal protein kinetics in young adults. / Volpi, Elena; Lucidi, Paola; Bolli, Geremia B.; Santeusanio, Fausto; De Feo, Pierpaolo.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 83, No. 12, 1998, p. 4363-4367.

Research output: Contribution to journalArticle

Volpi, E, Lucidi, P, Bolli, GB, Santeusanio, F & De Feo, P 1998, 'Gender differences in basal protein kinetics in young adults', Journal of Clinical Endocrinology and Metabolism, vol. 83, no. 12, pp. 4363-4367.
Volpi, Elena ; Lucidi, Paola ; Bolli, Geremia B. ; Santeusanio, Fausto ; De Feo, Pierpaolo. / Gender differences in basal protein kinetics in young adults. In: Journal of Clinical Endocrinology and Metabolism. 1998 ; Vol. 83, No. 12. pp. 4363-4367.
@article{101191b8150346e18af5f9933d75a747,
title = "Gender differences in basal protein kinetics in young adults",
abstract = "Gender affects energy expenditure and influences the relative utilization of carbohydrate and fat as fuels. However, little is known about the possible effects of gender on protein metabolism. Thus, we compared whole body and plasma (albumin and fibrinogen) protein kinetics in the basal postabsorptive state in young, untrained volunteers divided into two groups according to gender (women: n = 17; age, 24 ± 4 yr; men: n = 17; age, 25 ± 2 yr). The two groups were matched for body mass index. Protein kinetics were measured by means of L-[1-14C]leucine infusion. The leucine whole body rate of appearance, an index of proteolysis, and nonoxidative rate of disappearance, an index of protein synthesis, were similar in the two groups. However, the leucine oxidation rate was significantly lower in women compared to men (0.23 ± 0.07 vs. 0.31 ± 0.08 μnol/kg·min; P = 0.0062). Similar results were obtained when data were adjusted for estimated body composition. Albumin and fibrinogen fractional secretion rates were not different in the two groups. In conclusion, in the basal state leucine oxidation is lower in women than in men regardless of body composition. This could be one of the factors contributing to the lower metabolic rate in women.",
author = "Elena Volpi and Paola Lucidi and Bolli, {Geremia B.} and Fausto Santeusanio and {De Feo}, Pierpaolo",
year = "1998",
language = "English (US)",
volume = "83",
pages = "4363--4367",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "12",

}

TY - JOUR

T1 - Gender differences in basal protein kinetics in young adults

AU - Volpi, Elena

AU - Lucidi, Paola

AU - Bolli, Geremia B.

AU - Santeusanio, Fausto

AU - De Feo, Pierpaolo

PY - 1998

Y1 - 1998

N2 - Gender affects energy expenditure and influences the relative utilization of carbohydrate and fat as fuels. However, little is known about the possible effects of gender on protein metabolism. Thus, we compared whole body and plasma (albumin and fibrinogen) protein kinetics in the basal postabsorptive state in young, untrained volunteers divided into two groups according to gender (women: n = 17; age, 24 ± 4 yr; men: n = 17; age, 25 ± 2 yr). The two groups were matched for body mass index. Protein kinetics were measured by means of L-[1-14C]leucine infusion. The leucine whole body rate of appearance, an index of proteolysis, and nonoxidative rate of disappearance, an index of protein synthesis, were similar in the two groups. However, the leucine oxidation rate was significantly lower in women compared to men (0.23 ± 0.07 vs. 0.31 ± 0.08 μnol/kg·min; P = 0.0062). Similar results were obtained when data were adjusted for estimated body composition. Albumin and fibrinogen fractional secretion rates were not different in the two groups. In conclusion, in the basal state leucine oxidation is lower in women than in men regardless of body composition. This could be one of the factors contributing to the lower metabolic rate in women.

AB - Gender affects energy expenditure and influences the relative utilization of carbohydrate and fat as fuels. However, little is known about the possible effects of gender on protein metabolism. Thus, we compared whole body and plasma (albumin and fibrinogen) protein kinetics in the basal postabsorptive state in young, untrained volunteers divided into two groups according to gender (women: n = 17; age, 24 ± 4 yr; men: n = 17; age, 25 ± 2 yr). The two groups were matched for body mass index. Protein kinetics were measured by means of L-[1-14C]leucine infusion. The leucine whole body rate of appearance, an index of proteolysis, and nonoxidative rate of disappearance, an index of protein synthesis, were similar in the two groups. However, the leucine oxidation rate was significantly lower in women compared to men (0.23 ± 0.07 vs. 0.31 ± 0.08 μnol/kg·min; P = 0.0062). Similar results were obtained when data were adjusted for estimated body composition. Albumin and fibrinogen fractional secretion rates were not different in the two groups. In conclusion, in the basal state leucine oxidation is lower in women than in men regardless of body composition. This could be one of the factors contributing to the lower metabolic rate in women.

UR - http://www.scopus.com/inward/record.url?scp=0032460950&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032460950&partnerID=8YFLogxK

M3 - Article

VL - 83

SP - 4363

EP - 4367

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 12

ER -