Gender, racial, and ethnic disclosure in nih k-award funded diabetes and obesity clinical trials

Carlos Guevara, Chad Cook, Natalie Herback, Ricardo Pietrobon, Danny O. Jacobs, Thomas Parker Vail

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In 1993, the National Institutes of Health (NIH) passed The Revitalization Act (Subtitle B) which mandated that all NIH funded clinical trials have "appropriate representation" of minority and women subjects. Our aim was to evaluate the impact of the mandate by examining the reporting and inclusion of minority and female subjects into NIH K-Award funded clinical trials, addressing the minority predominant diagnoses of diabetes and clinical obesity. Using the CRISP search engine and PUBMED, we selected publications published by the National Institute on Aging (NIA) and National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) K-grant recipients during 1989-2004, associated with all the diabetes and obesity clinical trials. Studies were stratified into three timeline categories (1989-1993, pre-mandate; 1993-1996, postmandate, and 1997-present, well past mandate) to evaluate trends in the recruiting of minorities and women before, during, and after the passing of the Revitalization Act. Of the 165 papers, only 37% disclosed race, a number that did not improve over time (p=.15), whereas 92% disclosed gender. Clinical trials that focused on females increased across the 3 timeframes (p < .001) for diabetes studies but not obesity studies. Overall, disclosure of race declined over the 3 timeframes whereas individually, the disclosure of African Americans improved.

Original languageEnglish (US)
Pages (from-to)311-324
Number of pages14
JournalAccountability in Research
Volume13
Issue number4
DOIs
StatePublished - 2006
Externally publishedYes

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Disclosure
chronic illness
National Institutes of Health (U.S.)
Obesity
minority
Clinical Trials
gender
National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)
National Institute on Aging (U.S.)
health
act
Search Engine
Organized Financing
African Americans
search engine
grant
Publications
recipient
inclusion
Disease

Keywords

  • Diabetes
  • Gender
  • K grant
  • Minority
  • Nih revitalization act
  • Obesity

ASJC Scopus subject areas

  • Education
  • Library and Information Sciences
  • Medicine(all)

Cite this

Gender, racial, and ethnic disclosure in nih k-award funded diabetes and obesity clinical trials. / Guevara, Carlos; Cook, Chad; Herback, Natalie; Pietrobon, Ricardo; Jacobs, Danny O.; Vail, Thomas Parker.

In: Accountability in Research, Vol. 13, No. 4, 2006, p. 311-324.

Research output: Contribution to journalArticle

Guevara, C, Cook, C, Herback, N, Pietrobon, R, Jacobs, DO & Vail, TP 2006, 'Gender, racial, and ethnic disclosure in nih k-award funded diabetes and obesity clinical trials', Accountability in Research, vol. 13, no. 4, pp. 311-324. https://doi.org/10.1080/08989620601003380
Guevara, Carlos ; Cook, Chad ; Herback, Natalie ; Pietrobon, Ricardo ; Jacobs, Danny O. ; Vail, Thomas Parker. / Gender, racial, and ethnic disclosure in nih k-award funded diabetes and obesity clinical trials. In: Accountability in Research. 2006 ; Vol. 13, No. 4. pp. 311-324.
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