Gender-specific effect of overexpression of sFlt-1 in pregnant mice on fetal programming of blood pressure in the offspring later in life

Fangxian Lu, Egle Bytautiene, Esther Tamayo, Phyllis Gamble, Garland D. Anderson, Gary Hankins, Monica Longo, George Saade

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Objective: The purpose of this study was to determine whether fetal programming of adult blood pressure is altered in a previously characterized mouse model of preeclampsia that was induced by sFlt-1. Study Design: CD-1 mouse mothers at day 8 of gestation were injected with an adenovirus carrying Flt 1-3 (109 plaque-forming units) or with an adenovirus carrying mFc as control (109 plaque-forming units). The resulting pups were followed until 6 months of age, at which time blood pressure (BP) was recorded continuously for 6 days. The offspring weight was also recorded from weaning until adulthood. Results: BP was significantly higher in the male offspring that were born to sFlt-1-treated mothers compared with the controls. Male offspring from sFlt-1-treated mothers were significantly smaller from weaning until adulthood. However, there were no significant differences in BP and postweaning weight in female offspring between the 2 groups. Conclusion: Our findings highlight the role of the intrauterine environment in the developmental origin of adult disease.

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Volume197
Issue number4
DOIs
StatePublished - Oct 2007

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Keywords

  • CD-1 mice
  • developmental origin
  • fetal programming
  • preeclampsia
  • sFlt-1

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

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