Gene differences between the sex ratio and standard gene arrangements of the X chromosome and linkage disequilibrium between loci in the standard gene arrangement of the X chromosome in Drosophila pseudoobscura

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Abstract

The Standard and Sex Ratio gene arrangements of the X chromosome of D. pseudobscura differ from each other in allele frequencies at the four X chromosome loci, esterase 5, adult acid phosphatase 6, phosphoglucomutase 1 and octanol dehydrogenase 3. The Standard arrangement which is the common arrangement in all populations is polymorphic at these loci in varying degrees, the geographically less widespread Sex Ratio arrangement has little polymorphism and is genically predominantly E 5 (1.04) AP 6- Pgm1(1.0) ODH 3(1.10). The Sex Ratio arrangement from different populations is alike at all of the four loci, the Standard arrangement shows some gene frequency differences among populations. The Standard and Sex Ratio arrangements differ from each other by three inversions which suggests that the two arrangements are 'old'. Gene differences between these two chromosome arrangements can be explained due to differential natural selection of alleles in the Standard and Sex Ratio arrangements. The order and percentage of recombination among these four loci in the Standard arrangement are: E 5-.294-AP 6-.335-Pgm 1-.024-ODH 3. The Standard X chromosomes from four different wild populations were analyzed for evidence of linkage disequilibrium between pairs of loci at these four loci. No evidence of linkage disequilibrium between pairs of loci was obtained. However, when linkages involving simultaneously three loci, E 5, AP 6 and Pgm 1 are considered, then significant departure from linkage equilibrium is observed.

Original languageEnglish (US)
Pages (from-to)795-804
Number of pages10
JournalGenetics
Volume77
Issue number4
StatePublished - 1974
Externally publishedYes

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Gene Order
Sex Ratio
Linkage Disequilibrium
X Chromosome
Drosophila
Genes
Gene Frequency
Population
Chromosomes, Human, 13-15
Phosphoglucomutase
1-Octanol
Genetic Selection
Esterases
Acid Phosphatase
Genetic Recombination
Chromosomes
Alleles

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

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abstract = "The Standard and Sex Ratio gene arrangements of the X chromosome of D. pseudobscura differ from each other in allele frequencies at the four X chromosome loci, esterase 5, adult acid phosphatase 6, phosphoglucomutase 1 and octanol dehydrogenase 3. The Standard arrangement which is the common arrangement in all populations is polymorphic at these loci in varying degrees, the geographically less widespread Sex Ratio arrangement has little polymorphism and is genically predominantly E 5 (1.04) AP 6- Pgm1(1.0) ODH 3(1.10). The Sex Ratio arrangement from different populations is alike at all of the four loci, the Standard arrangement shows some gene frequency differences among populations. The Standard and Sex Ratio arrangements differ from each other by three inversions which suggests that the two arrangements are 'old'. Gene differences between these two chromosome arrangements can be explained due to differential natural selection of alleles in the Standard and Sex Ratio arrangements. The order and percentage of recombination among these four loci in the Standard arrangement are: E 5-.294-AP 6-.335-Pgm 1-.024-ODH 3. The Standard X chromosomes from four different wild populations were analyzed for evidence of linkage disequilibrium between pairs of loci at these four loci. No evidence of linkage disequilibrium between pairs of loci was obtained. However, when linkages involving simultaneously three loci, E 5, AP 6 and Pgm 1 are considered, then significant departure from linkage equilibrium is observed.",
author = "Satya Prakash",
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pages = "795--804",
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N2 - The Standard and Sex Ratio gene arrangements of the X chromosome of D. pseudobscura differ from each other in allele frequencies at the four X chromosome loci, esterase 5, adult acid phosphatase 6, phosphoglucomutase 1 and octanol dehydrogenase 3. The Standard arrangement which is the common arrangement in all populations is polymorphic at these loci in varying degrees, the geographically less widespread Sex Ratio arrangement has little polymorphism and is genically predominantly E 5 (1.04) AP 6- Pgm1(1.0) ODH 3(1.10). The Sex Ratio arrangement from different populations is alike at all of the four loci, the Standard arrangement shows some gene frequency differences among populations. The Standard and Sex Ratio arrangements differ from each other by three inversions which suggests that the two arrangements are 'old'. Gene differences between these two chromosome arrangements can be explained due to differential natural selection of alleles in the Standard and Sex Ratio arrangements. The order and percentage of recombination among these four loci in the Standard arrangement are: E 5-.294-AP 6-.335-Pgm 1-.024-ODH 3. The Standard X chromosomes from four different wild populations were analyzed for evidence of linkage disequilibrium between pairs of loci at these four loci. No evidence of linkage disequilibrium between pairs of loci was obtained. However, when linkages involving simultaneously three loci, E 5, AP 6 and Pgm 1 are considered, then significant departure from linkage equilibrium is observed.

AB - The Standard and Sex Ratio gene arrangements of the X chromosome of D. pseudobscura differ from each other in allele frequencies at the four X chromosome loci, esterase 5, adult acid phosphatase 6, phosphoglucomutase 1 and octanol dehydrogenase 3. The Standard arrangement which is the common arrangement in all populations is polymorphic at these loci in varying degrees, the geographically less widespread Sex Ratio arrangement has little polymorphism and is genically predominantly E 5 (1.04) AP 6- Pgm1(1.0) ODH 3(1.10). The Sex Ratio arrangement from different populations is alike at all of the four loci, the Standard arrangement shows some gene frequency differences among populations. The Standard and Sex Ratio arrangements differ from each other by three inversions which suggests that the two arrangements are 'old'. Gene differences between these two chromosome arrangements can be explained due to differential natural selection of alleles in the Standard and Sex Ratio arrangements. The order and percentage of recombination among these four loci in the Standard arrangement are: E 5-.294-AP 6-.335-Pgm 1-.024-ODH 3. The Standard X chromosomes from four different wild populations were analyzed for evidence of linkage disequilibrium between pairs of loci at these four loci. No evidence of linkage disequilibrium between pairs of loci was obtained. However, when linkages involving simultaneously three loci, E 5, AP 6 and Pgm 1 are considered, then significant departure from linkage equilibrium is observed.

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