Gene disruption and immunity in experimental colitis

Charles O. Elson, Astrid Konrad, Yingzi Cong, Casey T. Weaver

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In summary, many experimental models of IBD have been generated in the past decade using genetic manipulation. The new experimental models can be placed into several major categories based on probable pathogenic mechanisms. These models have affirmed the major working hypothesis of IBD pathogenesis, that it is due to a dysregulated immune response to the enteric bacterial flora (or members thereof) in a genetically susceptible host. Insights gained from these experimental models will likely translate into new forms of therapy for patients in this coming decade.

Original languageEnglish (US)
JournalInflammatory Bowel Diseases
Volume10
Issue numberSUPPL. 1
StatePublished - Feb 2004
Externally publishedYes

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Colitis
Immunity
Theoretical Models
Genes
Therapeutics

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Elson, C. O., Konrad, A., Cong, Y., & Weaver, C. T. (2004). Gene disruption and immunity in experimental colitis. Inflammatory Bowel Diseases, 10(SUPPL. 1).

Gene disruption and immunity in experimental colitis. / Elson, Charles O.; Konrad, Astrid; Cong, Yingzi; Weaver, Casey T.

In: Inflammatory Bowel Diseases, Vol. 10, No. SUPPL. 1, 02.2004.

Research output: Contribution to journalArticle

Elson, CO, Konrad, A, Cong, Y & Weaver, CT 2004, 'Gene disruption and immunity in experimental colitis', Inflammatory Bowel Diseases, vol. 10, no. SUPPL. 1.
Elson, Charles O. ; Konrad, Astrid ; Cong, Yingzi ; Weaver, Casey T. / Gene disruption and immunity in experimental colitis. In: Inflammatory Bowel Diseases. 2004 ; Vol. 10, No. SUPPL. 1.
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