Gene expression analysis in burn wounds of rats

Marcus Spies, Mohan R.K. Dasu, Nenad Svrakic, Olivera Nesic, Robert E. Barrow, J. Regino Perez-Polo, David N. Herndon

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

The events occurring early in the burn wound trigger a sequence of local and systemic responses that influence cell and tissue survival and, consequently, wound healing and recovery. Using high-density oligonucleotide arrays we identified gene expression patterns in skin samples taken from a region of injury in the burn rat model. The associated genomic events include the differential expression of genes involved in cell survival and death, cell growth regulation, cell metabolism, inflammation, and immune response. The functional gene cluster detected and their time appearance matched the time sequence known to occur in burn wound healing.

Original languageEnglish (US)
Pages (from-to)R918-R930
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume283
Issue number4 52-4
StatePublished - Oct 1 2002

Keywords

  • Gene expression profile
  • Microarray
  • Rat burn model
  • Skin
  • Wound healing

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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    Spies, M., Dasu, M. R. K., Svrakic, N., Nesic, O., Barrow, R. E., Perez-Polo, J. R., & Herndon, D. N. (2002). Gene expression analysis in burn wounds of rats. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 283(4 52-4), R918-R930.