Gene expression profile of an adenomyoepithelioma of the breast with a reciprocal translocation involving chromosomes 8 and 16

Zoran Gatalica, Gopalrao Velagaleti, Helena Kuivaniemi, Gerard Tromp, Juan Palazzo, Kerry M. Graves, Michelle Guigneaux, Thomas Wood, Mala Sinha, Bruce Luxon

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Myoepithelium is an integral part of the mammary ductal and lobular architecture, positioned between luminal cells and the basement membrane. We describe the first report on cytogenetic findings in an adenomyoepithelioma of the breast with a balanced t(8;16)(p23;q21), and provide gene expression profile using Affymetrix GeneChip U95AV2 (Affymetrix, Santa Clara, CA). Differential analysis identified 857 genes with 2-fold or more mRNA change in comparison to pooled normal breast control; immunohistochemical analysis was used to confirm these results in a limited number of genes. Expression results were grouped based on the chromosomal location of the genes and associated protein function, and identified several potential pathogenetic mechanisms (autocrine and paracrine growth stimuli) in the development of myoepithelial tumors.

Original languageEnglish (US)
Pages (from-to)14-22
Number of pages9
JournalCancer Genetics and Cytogenetics
Volume156
Issue number1
DOIs
StatePublished - Jan 1 2005

Fingerprint

Adenomyoepithelioma
Chromosomes, Human, Pair 16
Chromosomes, Human, Pair 8
Transcriptome
Breast
Myoepithelioma
Basement Membrane
Cytogenetics
Genes
Cell Membrane
Messenger RNA
Growth
Proteins

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Gene expression profile of an adenomyoepithelioma of the breast with a reciprocal translocation involving chromosomes 8 and 16. / Gatalica, Zoran; Velagaleti, Gopalrao; Kuivaniemi, Helena; Tromp, Gerard; Palazzo, Juan; Graves, Kerry M.; Guigneaux, Michelle; Wood, Thomas; Sinha, Mala; Luxon, Bruce.

In: Cancer Genetics and Cytogenetics, Vol. 156, No. 1, 01.01.2005, p. 14-22.

Research output: Contribution to journalArticle

Gatalica, Z, Velagaleti, G, Kuivaniemi, H, Tromp, G, Palazzo, J, Graves, KM, Guigneaux, M, Wood, T, Sinha, M & Luxon, B 2005, 'Gene expression profile of an adenomyoepithelioma of the breast with a reciprocal translocation involving chromosomes 8 and 16', Cancer Genetics and Cytogenetics, vol. 156, no. 1, pp. 14-22. https://doi.org/10.1016/j.cancergencyto.2004.04.024
Gatalica, Zoran ; Velagaleti, Gopalrao ; Kuivaniemi, Helena ; Tromp, Gerard ; Palazzo, Juan ; Graves, Kerry M. ; Guigneaux, Michelle ; Wood, Thomas ; Sinha, Mala ; Luxon, Bruce. / Gene expression profile of an adenomyoepithelioma of the breast with a reciprocal translocation involving chromosomes 8 and 16. In: Cancer Genetics and Cytogenetics. 2005 ; Vol. 156, No. 1. pp. 14-22.
@article{8cefe0412f3b41b8b45fd6c3d4d48018,
title = "Gene expression profile of an adenomyoepithelioma of the breast with a reciprocal translocation involving chromosomes 8 and 16",
abstract = "Myoepithelium is an integral part of the mammary ductal and lobular architecture, positioned between luminal cells and the basement membrane. We describe the first report on cytogenetic findings in an adenomyoepithelioma of the breast with a balanced t(8;16)(p23;q21), and provide gene expression profile using Affymetrix GeneChip U95AV2 (Affymetrix, Santa Clara, CA). Differential analysis identified 857 genes with 2-fold or more mRNA change in comparison to pooled normal breast control; immunohistochemical analysis was used to confirm these results in a limited number of genes. Expression results were grouped based on the chromosomal location of the genes and associated protein function, and identified several potential pathogenetic mechanisms (autocrine and paracrine growth stimuli) in the development of myoepithelial tumors.",
author = "Zoran Gatalica and Gopalrao Velagaleti and Helena Kuivaniemi and Gerard Tromp and Juan Palazzo and Graves, {Kerry M.} and Michelle Guigneaux and Thomas Wood and Mala Sinha and Bruce Luxon",
year = "2005",
month = "1",
day = "1",
doi = "10.1016/j.cancergencyto.2004.04.024",
language = "English (US)",
volume = "156",
pages = "14--22",
journal = "Cancer Genetics and Cytogenetics",
issn = "0165-4608",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Gene expression profile of an adenomyoepithelioma of the breast with a reciprocal translocation involving chromosomes 8 and 16

AU - Gatalica, Zoran

AU - Velagaleti, Gopalrao

AU - Kuivaniemi, Helena

AU - Tromp, Gerard

AU - Palazzo, Juan

AU - Graves, Kerry M.

AU - Guigneaux, Michelle

AU - Wood, Thomas

AU - Sinha, Mala

AU - Luxon, Bruce

PY - 2005/1/1

Y1 - 2005/1/1

N2 - Myoepithelium is an integral part of the mammary ductal and lobular architecture, positioned between luminal cells and the basement membrane. We describe the first report on cytogenetic findings in an adenomyoepithelioma of the breast with a balanced t(8;16)(p23;q21), and provide gene expression profile using Affymetrix GeneChip U95AV2 (Affymetrix, Santa Clara, CA). Differential analysis identified 857 genes with 2-fold or more mRNA change in comparison to pooled normal breast control; immunohistochemical analysis was used to confirm these results in a limited number of genes. Expression results were grouped based on the chromosomal location of the genes and associated protein function, and identified several potential pathogenetic mechanisms (autocrine and paracrine growth stimuli) in the development of myoepithelial tumors.

AB - Myoepithelium is an integral part of the mammary ductal and lobular architecture, positioned between luminal cells and the basement membrane. We describe the first report on cytogenetic findings in an adenomyoepithelioma of the breast with a balanced t(8;16)(p23;q21), and provide gene expression profile using Affymetrix GeneChip U95AV2 (Affymetrix, Santa Clara, CA). Differential analysis identified 857 genes with 2-fold or more mRNA change in comparison to pooled normal breast control; immunohistochemical analysis was used to confirm these results in a limited number of genes. Expression results were grouped based on the chromosomal location of the genes and associated protein function, and identified several potential pathogenetic mechanisms (autocrine and paracrine growth stimuli) in the development of myoepithelial tumors.

UR - http://www.scopus.com/inward/record.url?scp=10044257779&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10044257779&partnerID=8YFLogxK

U2 - 10.1016/j.cancergencyto.2004.04.024

DO - 10.1016/j.cancergencyto.2004.04.024

M3 - Article

C2 - 15588851

AN - SCOPUS:10044257779

VL - 156

SP - 14

EP - 22

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

SN - 0165-4608

IS - 1

ER -