Gene expression profile of an adenomyoepithelioma of the breast with a reciprocal translocation involving chromosomes 8 and 16

Zoran Gatalica, Gopalrao Velagaleti, Helena Kuivaniemi, Gerard Tromp, Juan Palazzo, Kerry M. Graves, Michelle Guigneaux, Thomas Wood, Mala Sinha, Bruce Luxon

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Myoepithelium is an integral part of the mammary ductal and lobular architecture, positioned between luminal cells and the basement membrane. We describe the first report on cytogenetic findings in an adenomyoepithelioma of the breast with a balanced t(8;16)(p23;q21), and provide gene expression profile using Affymetrix GeneChip U95AV2 (Affymetrix, Santa Clara, CA). Differential analysis identified 857 genes with 2-fold or more mRNA change in comparison to pooled normal breast control; immunohistochemical analysis was used to confirm these results in a limited number of genes. Expression results were grouped based on the chromosomal location of the genes and associated protein function, and identified several potential pathogenetic mechanisms (autocrine and paracrine growth stimuli) in the development of myoepithelial tumors.

Original languageEnglish (US)
Pages (from-to)14-22
Number of pages9
JournalCancer Genetics and Cytogenetics
Volume156
Issue number1
DOIs
StatePublished - Jan 1 2005

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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    Gatalica, Z., Velagaleti, G., Kuivaniemi, H., Tromp, G., Palazzo, J., Graves, K. M., Guigneaux, M., Wood, T., Sinha, M., & Luxon, B. (2005). Gene expression profile of an adenomyoepithelioma of the breast with a reciprocal translocation involving chromosomes 8 and 16. Cancer Genetics and Cytogenetics, 156(1), 14-22. https://doi.org/10.1016/j.cancergencyto.2004.04.024