GeneChip analyses of global transcriptional responses of murine macrophages to the lethal toxin of Bacillus anthracis

Jason E. Comer, Cristi L. Galindo, Ashok K. Chopra, Johnny W. Peterson

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

We performed GeneChip analyses on RNA from Bacillus anthracis lethal toxin (LeTx)-treated RAW 264.7 murine macrophages to investigate global effects of anthrax toxin on host cell gene expression. Stringent analysis of data revealed that the expression of several mitogen-activated protein kinase kinase-regulatory genes was affected within 1.5 h post-exposure to LeTx. By 3.0 h, the expression of 103 genes was altered, including those involved in intracellular signaling, energy production, and protein metabolism.

Original languageEnglish (US)
Pages (from-to)1879-1885
Number of pages7
JournalInfection and immunity
Volume73
Issue number3
DOIs
StatePublished - Mar 1 2005

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ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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