GeneChip analyses of global transcriptional responses of murine macrophages to the lethal toxin of Bacillus anthracis

Jason Comer, Cristi L. Galindo, Ashok Chopra, Johnny Peterson

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

We performed GeneChip analyses on RNA from Bacillus anthracis lethal toxin (LeTx)-treated RAW 264.7 murine macrophages to investigate global effects of anthrax toxin on host cell gene expression. Stringent analysis of data revealed that the expression of several mitogen-activated protein kinase kinase-regulatory genes was affected within 1.5 h post-exposure to LeTx. By 3.0 h, the expression of 103 genes was altered, including those involved in intracellular signaling, energy production, and protein metabolism.

Original languageEnglish (US)
Pages (from-to)1879-1885
Number of pages7
JournalInfection and Immunity
Volume73
Issue number3
DOIs
StatePublished - Mar 2005

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Macrophages
Gene Expression
Mitogen-Activated Protein Kinase Kinases
Regulator Genes
RNA
Proteins
anthrax toxin

ASJC Scopus subject areas

  • Immunology

Cite this

GeneChip analyses of global transcriptional responses of murine macrophages to the lethal toxin of Bacillus anthracis. / Comer, Jason; Galindo, Cristi L.; Chopra, Ashok; Peterson, Johnny.

In: Infection and Immunity, Vol. 73, No. 3, 03.2005, p. 1879-1885.

Research output: Contribution to journalArticle

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