Abstract
We performed GeneChip analyses on RNA from Bacillus anthracis lethal toxin (LeTx)-treated RAW 264.7 murine macrophages to investigate global effects of anthrax toxin on host cell gene expression. Stringent analysis of data revealed that the expression of several mitogen-activated protein kinase kinase-regulatory genes was affected within 1.5 h post-exposure to LeTx. By 3.0 h, the expression of 103 genes was altered, including those involved in intracellular signaling, energy production, and protein metabolism.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1879-1885 |
| Number of pages | 7 |
| Journal | Infection and immunity |
| Volume | 73 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2005 |
ASJC Scopus subject areas
- Parasitology
- Microbiology
- Immunology
- Infectious Diseases
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