General anaesthetics: synaptic depression consistent with increased membrane fluidity

P. W. Gage, O. Hamill

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

At normal anaesthetic concentrations, diethyl ether and halothane reduce the amplitude of end-plate potentials by increasing the rate of decay of the postsynaptic conductance change caused by acetylcholine. The increased decay rate is consistent with an increase in fluidity of the postsynaptic membrane, allowing more rapid relaxation of proteins following activation by acetylcholine.

Original languageEnglish (US)
Pages (from-to)61-65
Number of pages5
JournalNeuroscience Letters
Volume1
Issue number1
DOIs
StatePublished - Jul 1975
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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