General anaesthetics: synaptic depression consistent with increased membrane fluidity

P. W. Gage; O. Hamill

doi:10.1016/0304-3940(75)90013-0

General anaesthetics: synaptic depression consistent with increased membrane fluidity

P. W. Gage, O. Hamill

Research output: Contribution to journal › Article › peer-review

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Abstract

At normal anaesthetic concentrations, diethyl ether and halothane reduce the amplitude of end-plate potentials by increasing the rate of decay of the postsynaptic conductance change caused by acetylcholine. The increased decay rate is consistent with an increase in fluidity of the postsynaptic membrane, allowing more rapid relaxation of proteins following activation by acetylcholine.

Original language	English (US)
Pages (from-to)	61-65
Number of pages	5
Journal	Neuroscience Letters
Volume	1
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(75)90013-0
State	Published - Jul 1975
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(75)90013-0

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title = "General anaesthetics: synaptic depression consistent with increased membrane fluidity",

abstract = "At normal anaesthetic concentrations, diethyl ether and halothane reduce the amplitude of end-plate potentials by increasing the rate of decay of the postsynaptic conductance change caused by acetylcholine. The increased decay rate is consistent with an increase in fluidity of the postsynaptic membrane, allowing more rapid relaxation of proteins following activation by acetylcholine.",

author = "Gage, {P. W.} and O. Hamill",

note = "Funding Information: We R. Malbon and G. Seekee for technical assistance. grant from the National Health and Medical Research Council of Australia.",

year = "1975",

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doi = "10.1016/0304-3940(75)90013-0",

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AU - Hamill, O.

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PY - 1975/7

Y1 - 1975/7

N2 - At normal anaesthetic concentrations, diethyl ether and halothane reduce the amplitude of end-plate potentials by increasing the rate of decay of the postsynaptic conductance change caused by acetylcholine. The increased decay rate is consistent with an increase in fluidity of the postsynaptic membrane, allowing more rapid relaxation of proteins following activation by acetylcholine.

AB - At normal anaesthetic concentrations, diethyl ether and halothane reduce the amplitude of end-plate potentials by increasing the rate of decay of the postsynaptic conductance change caused by acetylcholine. The increased decay rate is consistent with an increase in fluidity of the postsynaptic membrane, allowing more rapid relaxation of proteins following activation by acetylcholine.

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General anaesthetics: synaptic depression consistent with increased membrane fluidity

Abstract

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