Generalized occurrence of the broadly antiviral substance UTIβ in mammalian sera

I. P. Singh, D. H. Coppenhaver, Ashok Chopra, S. Baron

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

This study compares the characteristics of naturally occurring antiviral activities in nonhuman mammalian sera to UTIβ (University of Texas virus inhibitor β), an innate, non-specific viral inhibitor found in human serum. The antiviral agent in sera from four different species appears to possess properties similar to those of UTIβ, e.g. molecular weight of 60 ± 10 kDa, broad spectrum antiviral activity, glycoprotein structure with antiviral oligosaccharide moiety(s) attached to a carrier protein, and inhibition of most viruses by preventing their attachment to target cells. These findings suggest that UTIβ or UTIβ-like virus inhibitors are a normal component of the non-specific immune defenses of mammals.

Original languageEnglish (US)
Pages (from-to)7-14
Number of pages8
JournalJournal of Biological Regulators and Homeostatic Agents
Volume7
Issue number1
StatePublished - 1993

Fingerprint

Antiviral Agents
Viruses
viruses
Serum
antiviral agents
transport proteins
Oligosaccharides
oligosaccharides
glycoproteins
Mammals
Glycoproteins
Carrier Proteins
Molecular Weight
mammals
molecular weight
cells

Keywords

  • antiviral agents
  • DNA viruses
  • glycoprotein
  • oligosaccharide
  • RNA viruses

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Endocrinology
  • Physiology
  • Immunology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Physiology (medical)

Cite this

Generalized occurrence of the broadly antiviral substance UTIβ in mammalian sera. / Singh, I. P.; Coppenhaver, D. H.; Chopra, Ashok; Baron, S.

In: Journal of Biological Regulators and Homeostatic Agents, Vol. 7, No. 1, 1993, p. 7-14.

Research output: Contribution to journalArticle

@article{fa9df81c0155417ea68dcbcd1b331b71,
title = "Generalized occurrence of the broadly antiviral substance UTIβ in mammalian sera",
abstract = "This study compares the characteristics of naturally occurring antiviral activities in nonhuman mammalian sera to UTIβ (University of Texas virus inhibitor β), an innate, non-specific viral inhibitor found in human serum. The antiviral agent in sera from four different species appears to possess properties similar to those of UTIβ, e.g. molecular weight of 60 ± 10 kDa, broad spectrum antiviral activity, glycoprotein structure with antiviral oligosaccharide moiety(s) attached to a carrier protein, and inhibition of most viruses by preventing their attachment to target cells. These findings suggest that UTIβ or UTIβ-like virus inhibitors are a normal component of the non-specific immune defenses of mammals.",
keywords = "antiviral agents, DNA viruses, glycoprotein, oligosaccharide, RNA viruses",
author = "Singh, {I. P.} and Coppenhaver, {D. H.} and Ashok Chopra and S. Baron",
year = "1993",
language = "English (US)",
volume = "7",
pages = "7--14",
journal = "Journal of Biological Regulators and Homeostatic Agents",
issn = "0393-974X",
publisher = "Biolife SAS",
number = "1",

}

TY - JOUR

T1 - Generalized occurrence of the broadly antiviral substance UTIβ in mammalian sera

AU - Singh, I. P.

AU - Coppenhaver, D. H.

AU - Chopra, Ashok

AU - Baron, S.

PY - 1993

Y1 - 1993

N2 - This study compares the characteristics of naturally occurring antiviral activities in nonhuman mammalian sera to UTIβ (University of Texas virus inhibitor β), an innate, non-specific viral inhibitor found in human serum. The antiviral agent in sera from four different species appears to possess properties similar to those of UTIβ, e.g. molecular weight of 60 ± 10 kDa, broad spectrum antiviral activity, glycoprotein structure with antiviral oligosaccharide moiety(s) attached to a carrier protein, and inhibition of most viruses by preventing their attachment to target cells. These findings suggest that UTIβ or UTIβ-like virus inhibitors are a normal component of the non-specific immune defenses of mammals.

AB - This study compares the characteristics of naturally occurring antiviral activities in nonhuman mammalian sera to UTIβ (University of Texas virus inhibitor β), an innate, non-specific viral inhibitor found in human serum. The antiviral agent in sera from four different species appears to possess properties similar to those of UTIβ, e.g. molecular weight of 60 ± 10 kDa, broad spectrum antiviral activity, glycoprotein structure with antiviral oligosaccharide moiety(s) attached to a carrier protein, and inhibition of most viruses by preventing their attachment to target cells. These findings suggest that UTIβ or UTIβ-like virus inhibitors are a normal component of the non-specific immune defenses of mammals.

KW - antiviral agents

KW - DNA viruses

KW - glycoprotein

KW - oligosaccharide

KW - RNA viruses

UR - http://www.scopus.com/inward/record.url?scp=0027223067&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027223067&partnerID=8YFLogxK

M3 - Article

VL - 7

SP - 7

EP - 14

JO - Journal of Biological Regulators and Homeostatic Agents

JF - Journal of Biological Regulators and Homeostatic Agents

SN - 0393-974X

IS - 1

ER -