Generalized occurrence of the broadly antiviral substance UTIβ in mammalian sera

I. P. Singh, D. H. Coppenhaver, A. K. Chopra, S. Baron

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

This study compares the characteristics of naturally occurring antiviral activities in nonhuman mammalian sera to UTIβ (University of Texas virus inhibitor β), an innate, non-specific viral inhibitor found in human serum. The antiviral agent in sera from four different species appears to possess properties similar to those of UTIβ, e.g. molecular weight of 60 ± 10 kDa, broad spectrum antiviral activity, glycoprotein structure with antiviral oligosaccharide moiety(s) attached to a carrier protein, and inhibition of most viruses by preventing their attachment to target cells. These findings suggest that UTIβ or UTIβ-like virus inhibitors are a normal component of the non-specific immune defenses of mammals.

Original languageEnglish (US)
Pages (from-to)7-14
Number of pages8
JournalJournal of biological regulators and homeostatic agents
Volume7
Issue number1
StatePublished - Jan 1 1993

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Keywords

  • DNA viruses
  • RNA viruses
  • antiviral agents
  • glycoprotein
  • oligosaccharide

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Physiology
  • Immunology
  • Oncology
  • Endocrinology
  • Physiology (medical)
  • Cancer Research

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