Genetic analysis of the diversity and origin of hantaviruses in Peromyscus leucopus mice in North America

Sergey P. Morzunov, Joan E. Rowe, Thomas Ksiazek, Clarence J. Peters, Stephen C St Jeor, Stuart T. Nichol

Research output: Contribution to journalArticle

124 Citations (Scopus)

Abstract

Nucleotide sequences were determined for the complete M genome segments of two distinct hantavirus genetic lineages which were detected in hantavirus antibody- and PCR-positive white-footed mice (Peromyscus leucopus) from Indiana and Oklahoma. Phylogenetic analyses indicated that although divergent from each other, the virus lineages in Indiana and Oklahoma were monophyletic and formed a newly identified unique ancestral branch within the clade of Sin Nombre-like viruses found in Peromyscus mice. Interestingly, P. leucopus- borne New York virus was found to be most closely related to the P. maniculatus-borne viruses, Sin Nombre and Monongahela, and monophyletic with Monongahela virus. In parallel, intraspecific phylogenetic relationships of P. leucopus were also determined, based on the amplification, sequencing, and analysis of the DNA fragment representing the replication control region of the rodent mitochondrial genome. P. leucopus mitochondrial DNA haplotypes were found to form four separate genetic clades, referred to here as Eastern, Central, Northwestern, and Southwestern groups. The distinct Indiana and Oklahoma virus lineages were detected in P. leucopus of the Eastern and Southwestern mitochondrial DNA haplotypes, respectively. Taken together, our current data suggests that both cospeciation of Peromyscus-borne hantaviruses with their specific rodent hosts and biogeographic factors (such as allopatric migrations, geographic separation, and isolation) have played important roles in establishment of the current genetic diversity and geographic distribution of Sin Nombre-like hantaviruses. In particular, the unusual position of New York virus on the virus phylogenetic tree is most consistent with an historically recent host-switching event.

Original languageEnglish (US)
Pages (from-to)57-64
Number of pages8
JournalJournal of Virology
Volume72
Issue number1
StatePublished - Jan 1998
Externally publishedYes

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Peromyscus
Hantavirus
Peromyscus leucopus
North America
genetic techniques and protocols
Viruses
viruses
Sin Nombre virus
mice
Mitochondrial DNA
Haplotypes
phylogeny
haplotypes
Rodent Control
mitochondrial DNA
rodents
Peromyscus maniculatus
Mitochondrial Genome
DNA Sequence Analysis
Rodentia

ASJC Scopus subject areas

  • Immunology

Cite this

Morzunov, S. P., Rowe, J. E., Ksiazek, T., Peters, C. J., Jeor, S. C. S., & Nichol, S. T. (1998). Genetic analysis of the diversity and origin of hantaviruses in Peromyscus leucopus mice in North America. Journal of Virology, 72(1), 57-64.

Genetic analysis of the diversity and origin of hantaviruses in Peromyscus leucopus mice in North America. / Morzunov, Sergey P.; Rowe, Joan E.; Ksiazek, Thomas; Peters, Clarence J.; Jeor, Stephen C St; Nichol, Stuart T.

In: Journal of Virology, Vol. 72, No. 1, 01.1998, p. 57-64.

Research output: Contribution to journalArticle

Morzunov, SP, Rowe, JE, Ksiazek, T, Peters, CJ, Jeor, SCS & Nichol, ST 1998, 'Genetic analysis of the diversity and origin of hantaviruses in Peromyscus leucopus mice in North America', Journal of Virology, vol. 72, no. 1, pp. 57-64.
Morzunov, Sergey P. ; Rowe, Joan E. ; Ksiazek, Thomas ; Peters, Clarence J. ; Jeor, Stephen C St ; Nichol, Stuart T. / Genetic analysis of the diversity and origin of hantaviruses in Peromyscus leucopus mice in North America. In: Journal of Virology. 1998 ; Vol. 72, No. 1. pp. 57-64.
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