Genetic analysis of viruses associated with emergence of Rift Valley fever in Saudi Arabia and Yemen, 2000-01

Trevor Shoemaker, Carla Boulianne, Martin J. Vincent, Linda Pezzanite, Mohammed M. Al-Qahtani, Yagub Al-Mazrou, Ali S. Khan, Pierre E. Rollin, Robert Swanepoel, Thomas Ksiazek, Stuart T. Nichol

Research output: Contribution to journalArticle

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Abstract

The first confirmed Rift Valley fever outbreak outside Africa was reported in September 2000, in the Arabian Peninsula. As of February 2001, a total of 884 hospitalized patients were identified in Saudi Arabia, with 124 deaths. In Yemen, 1,087 cases were estimated to have occurred, with 121 deaths. Laboratory diagnosis of Rift Valley fever virus (RVFV) infections included virus genetic detection and characterization of clinical specimens by reverse transcription-polymerase chain reaction, in addition to serologic tests and virus isolation. Genetic analysis of selected regions of virus S, M, and L RNA genome segments indicated little genetic variation among the viruses associated with disease. The Saudi Arabia and Yemen viruses were almost identical to those associated with earlier RVF epidemics in East Africa. Analysis of S, M, and L RNA genome segment sequence differences showed similar phylogenetic relationships among these viruses, indicating that genetic reassortment did not play an important role in the emergence of this virus in the Arabian Peninsula. These results are consistent with the recent introduction of RVFV into the Arabian Peninsula from East Africa.

Original languageEnglish (US)
Pages (from-to)1415-1420
Number of pages6
JournalEmerging Infectious Diseases
Volume8
Issue number12
StatePublished - Dec 1 2002
Externally publishedYes

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Rift Valley Fever
Yemen
Saudi Arabia
Viruses
Rift Valley fever virus
Eastern Africa
Genome
RNA
Clinical Laboratory Techniques
Serologic Tests
Virus Diseases
Reverse Transcription
Disease Outbreaks
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Shoemaker, T., Boulianne, C., Vincent, M. J., Pezzanite, L., Al-Qahtani, M. M., Al-Mazrou, Y., ... Nichol, S. T. (2002). Genetic analysis of viruses associated with emergence of Rift Valley fever in Saudi Arabia and Yemen, 2000-01. Emerging Infectious Diseases, 8(12), 1415-1420.

Genetic analysis of viruses associated with emergence of Rift Valley fever in Saudi Arabia and Yemen, 2000-01. / Shoemaker, Trevor; Boulianne, Carla; Vincent, Martin J.; Pezzanite, Linda; Al-Qahtani, Mohammed M.; Al-Mazrou, Yagub; Khan, Ali S.; Rollin, Pierre E.; Swanepoel, Robert; Ksiazek, Thomas; Nichol, Stuart T.

In: Emerging Infectious Diseases, Vol. 8, No. 12, 01.12.2002, p. 1415-1420.

Research output: Contribution to journalArticle

Shoemaker, T, Boulianne, C, Vincent, MJ, Pezzanite, L, Al-Qahtani, MM, Al-Mazrou, Y, Khan, AS, Rollin, PE, Swanepoel, R, Ksiazek, T & Nichol, ST 2002, 'Genetic analysis of viruses associated with emergence of Rift Valley fever in Saudi Arabia and Yemen, 2000-01', Emerging Infectious Diseases, vol. 8, no. 12, pp. 1415-1420.
Shoemaker T, Boulianne C, Vincent MJ, Pezzanite L, Al-Qahtani MM, Al-Mazrou Y et al. Genetic analysis of viruses associated with emergence of Rift Valley fever in Saudi Arabia and Yemen, 2000-01. Emerging Infectious Diseases. 2002 Dec 1;8(12):1415-1420.
Shoemaker, Trevor ; Boulianne, Carla ; Vincent, Martin J. ; Pezzanite, Linda ; Al-Qahtani, Mohammed M. ; Al-Mazrou, Yagub ; Khan, Ali S. ; Rollin, Pierre E. ; Swanepoel, Robert ; Ksiazek, Thomas ; Nichol, Stuart T. / Genetic analysis of viruses associated with emergence of Rift Valley fever in Saudi Arabia and Yemen, 2000-01. In: Emerging Infectious Diseases. 2002 ; Vol. 8, No. 12. pp. 1415-1420.
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