Genetic and antigenic characterization of H5 and H7 avian influenza viruses isolated from migratory waterfowl in Mongolia from 2017 to 2019

Ankhanbaatar Ulaankhuu, Enkhbold Bazarragchaa, Masatoshi Okamatsu, Takahiro Hiono, Khishgee Bodisaikhan, Tsolmon Amartuvshin, Jargalsaikhan Tserenjav, Tsogtbaatar Urangoo, Khanui Buyantogtokh, Keita Matsuno, Takanari Hattori, Tatsunari Kondoh, Masahiro Sato, Yoshihiro Takadate, Shiho Torii, Mao Isono, Kosuke Okuya, Takeshi Saito, Nodoka Kasajima, Yurie KidaJunki Maruyama, Manabu Igarashi, Ayato Takada, Hiroshi Kida, Damdinjav Batchuluun, Yoshihiro Sakoda

Research output: Contribution to journalArticle

Abstract

The circulation of highly pathogenic avian influenza viruses (HPAIVs) of various subtypes (e.g., H5N1, H5N6, H5N8, and H7N9) in poultry remains a global concern for animal and public health. Migratory waterfowls play important roles in the transmission of these viruses across countries. To monitor virus spread by wild birds, active surveillance for avian influenza in migratory waterfowl was conducted in Mongolia from 2015 to 2019. In total, 5000 fecal samples were collected from lakesides in central Mongolia, and 167 influenza A viruses were isolated. Two H5N3, four H7N3, and two H7N7 viruses were characterized in this study. The amino acid sequence at hemagglutinin (HA) cleavage site of those isolates suggested low pathogenicity in chickens. Phylogenetic analysis revealed that all H5 and H7 viruses were closely related to recent H5 and H7 low pathogenic avian influenza viruses (LPAIVs) isolated from wild birds in Asia and Europe. Antigenicity of H7Nx was similar to those of typical non-pathogenic avian influenza viruses (AIVs). While HPAIVs or A/Anhui/1/2013 (H7N9)-related LPAIVs were not detected in migratory waterfowl in Mongolia, sporadic introductions of AIVs including H5 and H7 viruses into Mongolia through the wild bird migration were identified. Thus, continued monitoring of H5 and H7 AIVs in both domestic and wild birds is needed for the early detection of HPAIVs spread into the country.

Original languageEnglish (US)
Pages (from-to)472-479
Number of pages8
JournalVirus Genes
Volume56
Issue number4
DOIs
StatePublished - Aug 1 2020

Keywords

  • Avian influenza
  • Characterization
  • Migratory waterfowl
  • Mongolia
  • Surveillance

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Virology

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    Ulaankhuu, A., Bazarragchaa, E., Okamatsu, M., Hiono, T., Bodisaikhan, K., Amartuvshin, T., Tserenjav, J., Urangoo, T., Buyantogtokh, K., Matsuno, K., Hattori, T., Kondoh, T., Sato, M., Takadate, Y., Torii, S., Isono, M., Okuya, K., Saito, T., Kasajima, N., ... Sakoda, Y. (2020). Genetic and antigenic characterization of H5 and H7 avian influenza viruses isolated from migratory waterfowl in Mongolia from 2017 to 2019. Virus Genes, 56(4), 472-479. https://doi.org/10.1007/s11262-020-01764-2