Genetic characterization of hantaviruses transmitted by the Korean field mouse (Apodemus peninsulae), Far East Russia

Kumari Lokugamage, Hiroaki Kariwa, Daisuke Hayasaka, Bai Zhong Cui, Takuya Iwasaki, Nandadeva Lokugamage, Leonid I. Ivanov, Vladimir I. Volkov, Vladimir A. Demenev, Raisa Slonova, Galina Kompanets, Tatyana Kushnaryova, Takeshi Kurata, Kenji Maeda, Koichi Araki, Tetsuya Mizutani, Kumiko Yoshimatsu, Jiro Arikawa, Ikuo Takashima

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

In an epizootiologic survey of 122 rodents captured in Vladivostok, Russia, antibodies positive for hantavirus were found in Apodemus peninsulae (4/70), A. agrarius (1/39), and Clethrionomys rufocanus (1/8). The hantavirus sequences identified in two seropositive A. peninsulae and two patients with hemorrhagic fever with renal syndrome (HFRS) from the Primorye region of Far East Russia were designated as Solovey and Primorye, respectively. The nucleotide sequences of the Solovey, Primorye, and Amur (obtained through GenBank) sequences were closely related (>92% identity). Solovey and Primorye sequences shared 84% nucleotide identity with the prototype Hantaan 76-118. Phylogenetic analysis also indicated a close relationship between Solovey, Primorye, Amur, and other viruses identified in Russia, China, and Korea. Our findings suggest that the Korean field mouse (A. peninsulae) is the reservoir for a hantavirus that causes HFRS over a vast area of east Asia, including Far East Russia.

Original languageEnglish (US)
Pages (from-to)768-776
Number of pages9
JournalEmerging infectious diseases
Volume8
Issue number8
DOIs
StatePublished - Aug 2002

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

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    Lokugamage, K., Kariwa, H., Hayasaka, D., Cui, B. Z., Iwasaki, T., Lokugamage, N., Ivanov, L. I., Volkov, V. I., Demenev, V. A., Slonova, R., Kompanets, G., Kushnaryova, T., Kurata, T., Maeda, K., Araki, K., Mizutani, T., Yoshimatsu, K., Arikawa, J., & Takashima, I. (2002). Genetic characterization of hantaviruses transmitted by the Korean field mouse (Apodemus peninsulae), Far East Russia. Emerging infectious diseases, 8(8), 768-776. https://doi.org/10.3201/eid0808.010494