Genetic characterization of the Wyeomyia group of orthobunyaviruses and their phylogenetic relationships

Rashmi Chowdhary, Craig Street, Amelia Travassos da Rosa, Marcio R T Nunes, Kok Keng Tee, Stephen K. Hutchison, Pedro F C Vasconcelos, Robert B. Tesh, W. Ian Lipkin, Thomas Briese

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Phylogenetic analyses can give new insights into the evolutionary history of viruses, especially of viruses with segmented genomes. However, sequence information for many viral families or genera is still limited and phylogenies based on single or short genome fragments can be misleading. We report the first genetic analysis of all three genome segments of Wyeomyia group viruses Wyeomyia, Taiassui, Macaua, Sororoca, Anhembi and Cachoeira Porteira (BeAr328208) in the genus Orthobunyavirus of the family Bunyaviridae. In addition, Tucunduba and Iaco viruses were identified as members of the Wyeomyia group. Features of Wyeomyia group members that distinguish them from other viruses in the Bunyamwera serogroup and from other orthobunyaviruses, including truncated NSs sequences that may not counteract the host's interferon response, were characterized. Our findings also suggest genome reassortment within the Wyeomyia group, identifying Macaua and Tucunduba viruses as M-segment reassortants that, in the case of Tucunduba virus, may have altered pathogenicity, stressing the need for wholegenome sequence information to facilitate characterization of orthobunyaviruses and their phylogenetic relationships.

Original languageEnglish (US)
Pages (from-to)1023-1034
Number of pages12
JournalJournal of General Virology
Volume93
Issue number5
DOIs
StatePublished - 2012

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Orthobunyavirus
Viruses
Genome
Bunyamwera virus
Bunyaviridae
Phylogeny
Interferons
Virulence
History

ASJC Scopus subject areas

  • Virology

Cite this

Chowdhary, R., Street, C., da Rosa, A. T., Nunes, M. R. T., Tee, K. K., Hutchison, S. K., ... Briese, T. (2012). Genetic characterization of the Wyeomyia group of orthobunyaviruses and their phylogenetic relationships. Journal of General Virology, 93(5), 1023-1034. https://doi.org/10.1099/vir.0.039479-0

Genetic characterization of the Wyeomyia group of orthobunyaviruses and their phylogenetic relationships. / Chowdhary, Rashmi; Street, Craig; da Rosa, Amelia Travassos; Nunes, Marcio R T; Tee, Kok Keng; Hutchison, Stephen K.; Vasconcelos, Pedro F C; Tesh, Robert B.; Ian Lipkin, W.; Briese, Thomas.

In: Journal of General Virology, Vol. 93, No. 5, 2012, p. 1023-1034.

Research output: Contribution to journalArticle

Chowdhary, R, Street, C, da Rosa, AT, Nunes, MRT, Tee, KK, Hutchison, SK, Vasconcelos, PFC, Tesh, RB, Ian Lipkin, W & Briese, T 2012, 'Genetic characterization of the Wyeomyia group of orthobunyaviruses and their phylogenetic relationships', Journal of General Virology, vol. 93, no. 5, pp. 1023-1034. https://doi.org/10.1099/vir.0.039479-0
Chowdhary, Rashmi ; Street, Craig ; da Rosa, Amelia Travassos ; Nunes, Marcio R T ; Tee, Kok Keng ; Hutchison, Stephen K. ; Vasconcelos, Pedro F C ; Tesh, Robert B. ; Ian Lipkin, W. ; Briese, Thomas. / Genetic characterization of the Wyeomyia group of orthobunyaviruses and their phylogenetic relationships. In: Journal of General Virology. 2012 ; Vol. 93, No. 5. pp. 1023-1034.
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