Genetic code redundancy and its influence on the encoded polypeptides

Paige S. Spencer, José M. Barral

    Research output: Contribution to journalArticle

    20 Citations (Scopus)

    Abstract

    The genetic code is said to be redundant in that the same amino acid residue can be encoded by multiple, so-called synonymous, codons. If all properties of synonymous codons were entirely equivalent, one would expect that they would be equally distributed along protein coding sequences. However, many studies over the last three decades have demonstrated that their distribution is not entirely random. It has been postulated that certain codons may be translated by the ribosome faster than others and thus their non-random distribution dictates how fast the ribosome moves along particular segments of the mRNA. The reasons behind such segmental variability in the rates of protein synthesis, and thus polypeptide emergence from the ribosome, have been explored by theoretical and experimental approaches. Predictions of the relative rates at which particular codons are translated and their impact on the nascent chain have not arrived at unequivocal conclusions. This is probably due, at least in part, to variation in the basis for classification of codons as "fast" or "slow", as well as variability in the number and types of genes and proteins analyzed. Recent methodological advances have allowed nucleotide-resolution studies of ribosome residency times in entire transcriptomes, which confirm the non-uniform movement of ribosomes along mRNAs and shed light on the actual determinants of rate control. Moreover, experiments have begun to emerge that systematically examine the influence of variations in ribosomal movement and the fate of the emerging polypeptide chain.

    Original languageEnglish
    Article numbere201204006
    JournalComputational and Structural Biotechnology Journal
    Volume1
    Issue number1
    DOIs
    StatePublished - 2012

    Fingerprint

    Genetic Code
    Polypeptides
    Ribosomes
    Codon
    Redundancy
    Proteins
    Peptides
    Messenger RNA
    Nucleotides
    Amino acids
    Genes
    Amino Acids
    Internship and Residency
    Transcriptome
    Experiments

    ASJC Scopus subject areas

    • Biotechnology
    • Biochemistry
    • Biophysics
    • Structural Biology
    • Genetics
    • Computer Science Applications

    Cite this

    Genetic code redundancy and its influence on the encoded polypeptides. / Spencer, Paige S.; Barral, José M.

    In: Computational and Structural Biotechnology Journal, Vol. 1, No. 1, e201204006, 2012.

    Research output: Contribution to journalArticle

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