Genetic control of immune response to sperm whale myoglobin in mice. I. T lymphocyte proliferative response under H-2-linked Ir gene control

K. Okuda, P. R. Christadoss, S. Twining, M. Z. Atassi, C. S. David

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Abstract

Studies on the genetic control of immune response to sperm whale myoglobin were initiated. As demonstrated in this paper, the T lymphocyte proliferative response to whale myoglobin is under H-2-linked Ir gene control. Mice of H-2(d), H-2(f), and H-2(s) haplotypes were high responders to the myoglobin, whereas haplotypes H-2 b, H-2(k), H-2(p), H-2(q), H-2(r) were low responders. The Ir gene(s) was localized between H-2K and H2D regions, since the recombinant strain A.TL(K(s)I(k)S(k)D(d)) was a low responder and A.TH (K(s)I(s)S(s)D(d)) was a high responder. Further studies with recombinant strains revealed that the expression of the high-responder I-A(d) or I-A(s) alleles was sufficient to give a good response, since strains D2.GD (d d b b b b b b) and B.10HTT (s s s s k k k d) were high responders. The expression of the I-C(d) allele in strains B10.A (k k k k k d d d) and B.10.A(5R)(b b b k k d d d) also gave high response, and thus suggested a second Ir gene, derived from the H-2(d) haplotype. The finding that expression of the I-C(s) allele in B10.S(8R) (k k ? ? s s s s) did not result in high response suggests the lack of the second Ir gene in the high-responder H-2(s) haplotype.

Original languageEnglish (US)
Pages (from-to)866-868
Number of pages3
JournalJournal of Immunology
Volume121
Issue number3
StatePublished - 1978
Externally publishedYes

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Sperm Whale
Myoglobin
Haplotypes
T-Lymphocytes
Alleles
Genes
Whales

ASJC Scopus subject areas

  • Immunology

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Genetic control of immune response to sperm whale myoglobin in mice. I. T lymphocyte proliferative response under H-2-linked Ir gene control. / Okuda, K.; Christadoss, P. R.; Twining, S.; Atassi, M. Z.; David, C. S.

In: Journal of Immunology, Vol. 121, No. 3, 1978, p. 866-868.

Research output: Contribution to journalArticle

Okuda, K. ; Christadoss, P. R. ; Twining, S. ; Atassi, M. Z. ; David, C. S. / Genetic control of immune response to sperm whale myoglobin in mice. I. T lymphocyte proliferative response under H-2-linked Ir gene control. In: Journal of Immunology. 1978 ; Vol. 121, No. 3. pp. 866-868.
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abstract = "Studies on the genetic control of immune response to sperm whale myoglobin were initiated. As demonstrated in this paper, the T lymphocyte proliferative response to whale myoglobin is under H-2-linked Ir gene control. Mice of H-2(d), H-2(f), and H-2(s) haplotypes were high responders to the myoglobin, whereas haplotypes H-2 b, H-2(k), H-2(p), H-2(q), H-2(r) were low responders. The Ir gene(s) was localized between H-2K and H2D regions, since the recombinant strain A.TL(K(s)I(k)S(k)D(d)) was a low responder and A.TH (K(s)I(s)S(s)D(d)) was a high responder. Further studies with recombinant strains revealed that the expression of the high-responder I-A(d) or I-A(s) alleles was sufficient to give a good response, since strains D2.GD (d d b b b b b b) and B.10HTT (s s s s k k k d) were high responders. The expression of the I-C(d) allele in strains B10.A (k k k k k d d d) and B.10.A(5R)(b b b k k d d d) also gave high response, and thus suggested a second Ir gene, derived from the H-2(d) haplotype. The finding that expression of the I-C(s) allele in B10.S(8R) (k k ? ? s s s s) did not result in high response suggests the lack of the second Ir gene in the high-responder H-2(s) haplotype.",
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