Genetic deficiency of estrogen receptor alpha fails to influence experimental autoimmune myasthenia gravis pathogenesis

Huibin Qi, Jing Li, Windy Allman, Shamsher S. Saini, Erdem Tüzün, Xiaorong Wu, D. Mark Estes, Premkumar Christadoss

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Autoimmune myasthenia gravis (MG) is characterized by T cell and antibody responses to muscle nicotinic acetylcholine receptor (AChR). It is well known that MG as other autoimmune diseases is more prevalent in women than men and estrogen administration enhances experimental autoimmune MG (EAMG) severity. To determine whether estrogen influences EAMG pathogenesis through estrogen receptor alpha (ERα) activation, ERα knockout (KO) and wild-type (WT) C57BL/6 mice were immunized with AChR. ERα KO mice were equally susceptible to EAMG as WT mice and exhibited comparable antibody and immunopathological responses to AChR, suggesting a lack of involvement of ERα in EAMG pathogenesis.

Original languageEnglish (US)
Pages (from-to)165-167
Number of pages3
JournalJournal of Neuroimmunology
Volume234
Issue number1-2
DOIs
StatePublished - May 2011

Fingerprint

Autoimmune Experimental Myasthenia Gravis
Estrogen Receptor alpha
Myasthenia Gravis
Cholinergic Receptors
Antibody Formation
Estrogens
Nicotinic Receptors
Inbred C57BL Mouse
Knockout Mice
Autoimmune Diseases
T-Lymphocytes
Muscles

Keywords

  • Autoimmunity
  • Estrogen receptor alpha
  • Myasthenia gravis

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Genetic deficiency of estrogen receptor alpha fails to influence experimental autoimmune myasthenia gravis pathogenesis. / Qi, Huibin; Li, Jing; Allman, Windy; Saini, Shamsher S.; Tüzün, Erdem; Wu, Xiaorong; Estes, D. Mark; Christadoss, Premkumar.

In: Journal of Neuroimmunology, Vol. 234, No. 1-2, 05.2011, p. 165-167.

Research output: Contribution to journalArticle

Qi, Huibin ; Li, Jing ; Allman, Windy ; Saini, Shamsher S. ; Tüzün, Erdem ; Wu, Xiaorong ; Estes, D. Mark ; Christadoss, Premkumar. / Genetic deficiency of estrogen receptor alpha fails to influence experimental autoimmune myasthenia gravis pathogenesis. In: Journal of Neuroimmunology. 2011 ; Vol. 234, No. 1-2. pp. 165-167.
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