Abstract
Autoimmune myasthenia gravis (MG) is characterized by T cell and antibody responses to muscle nicotinic acetylcholine receptor (AChR). It is well known that MG as other autoimmune diseases is more prevalent in women than men and estrogen administration enhances experimental autoimmune MG (EAMG) severity. To determine whether estrogen influences EAMG pathogenesis through estrogen receptor alpha (ERα) activation, ERα knockout (KO) and wild-type (WT) C57BL/6 mice were immunized with AChR. ERα KO mice were equally susceptible to EAMG as WT mice and exhibited comparable antibody and immunopathological responses to AChR, suggesting a lack of involvement of ERα in EAMG pathogenesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 165-167 |
| Number of pages | 3 |
| Journal | Journal of Neuroimmunology |
| Volume | 234 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - May 1 2011 |
Keywords
- Autoimmunity
- Estrogen receptor alpha
- Myasthenia gravis
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Neurology
- Clinical Neurology
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Cite this
Qi, H., Li, J., Allman, W., Saini, S. S., Tüzün, E., Wu, X., Estes, D. M., & Christadoss, P. (2011). Genetic deficiency of estrogen receptor alpha fails to influence experimental autoimmune myasthenia gravis pathogenesis. Journal of Neuroimmunology, 234(1-2), 165-167. https://doi.org/10.1016/j.jneuroim.2011.03.002