Genetic deficiency of estrogen receptor alpha fails to influence experimental autoimmune myasthenia gravis pathogenesis

Huibin Qi; Jing Li; Windy Allman; Shamsher S. Saini; Erdem Tüzün; Xiaorong Wu; D. Mark Estes; Premkumar Christadoss

doi:10.1016/j.jneuroim.2011.03.002

Genetic deficiency of estrogen receptor alpha fails to influence experimental autoimmune myasthenia gravis pathogenesis

Huibin Qi, Jing Li, Windy Allman, Shamsher S. Saini, Erdem Tüzün, Xiaorong Wu, D. Mark Estes, Premkumar Christadoss

Microbiology And Immunology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Autoimmune myasthenia gravis (MG) is characterized by T cell and antibody responses to muscle nicotinic acetylcholine receptor (AChR). It is well known that MG as other autoimmune diseases is more prevalent in women than men and estrogen administration enhances experimental autoimmune MG (EAMG) severity. To determine whether estrogen influences EAMG pathogenesis through estrogen receptor alpha (ERα) activation, ERα knockout (KO) and wild-type (WT) C57BL/6 mice were immunized with AChR. ERα KO mice were equally susceptible to EAMG as WT mice and exhibited comparable antibody and immunopathological responses to AChR, suggesting a lack of involvement of ERα in EAMG pathogenesis.

Original language	English (US)
Pages (from-to)	165-167
Number of pages	3
Journal	Journal of Neuroimmunology
Volume	234
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2011.03.002
State	Published - May 2011

Keywords

Autoimmunity
Estrogen receptor alpha
Myasthenia gravis

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

Access to Document

10.1016/j.jneuroim.2011.03.002

Cite this

@article{01a3163ca9d149ae9bd5b1538843e147,

title = "Genetic deficiency of estrogen receptor alpha fails to influence experimental autoimmune myasthenia gravis pathogenesis",

abstract = "Autoimmune myasthenia gravis (MG) is characterized by T cell and antibody responses to muscle nicotinic acetylcholine receptor (AChR). It is well known that MG as other autoimmune diseases is more prevalent in women than men and estrogen administration enhances experimental autoimmune MG (EAMG) severity. To determine whether estrogen influences EAMG pathogenesis through estrogen receptor alpha (ERα) activation, ERα knockout (KO) and wild-type (WT) C57BL/6 mice were immunized with AChR. ERα KO mice were equally susceptible to EAMG as WT mice and exhibited comparable antibody and immunopathological responses to AChR, suggesting a lack of involvement of ERα in EAMG pathogenesis.",

keywords = "Autoimmunity, Estrogen receptor alpha, Myasthenia gravis",

author = "Huibin Qi and Jing Li and Windy Allman and Saini, {Shamsher S.} and Erdem T{\"u}z{\"u}n and Xiaorong Wu and Estes, {D. Mark} and Premkumar Christadoss",

note = "Funding Information: We would like to thank Dr. Edward M. Curran for help in the breeding and genotyping of ERα KO mice. This work was supported by AFM .",

year = "2011",

month = may,

doi = "10.1016/j.jneuroim.2011.03.002",

language = "English (US)",

volume = "234",

pages = "165--167",

journal = "Advances in Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier",

number = "1-2",

}

TY - JOUR

T1 - Genetic deficiency of estrogen receptor alpha fails to influence experimental autoimmune myasthenia gravis pathogenesis

AU - Qi, Huibin

AU - Li, Jing

AU - Allman, Windy

AU - Saini, Shamsher S.

AU - Tüzün, Erdem

AU - Wu, Xiaorong

AU - Estes, D. Mark

AU - Christadoss, Premkumar

N1 - Funding Information: We would like to thank Dr. Edward M. Curran for help in the breeding and genotyping of ERα KO mice. This work was supported by AFM .

PY - 2011/5

Y1 - 2011/5

N2 - Autoimmune myasthenia gravis (MG) is characterized by T cell and antibody responses to muscle nicotinic acetylcholine receptor (AChR). It is well known that MG as other autoimmune diseases is more prevalent in women than men and estrogen administration enhances experimental autoimmune MG (EAMG) severity. To determine whether estrogen influences EAMG pathogenesis through estrogen receptor alpha (ERα) activation, ERα knockout (KO) and wild-type (WT) C57BL/6 mice were immunized with AChR. ERα KO mice were equally susceptible to EAMG as WT mice and exhibited comparable antibody and immunopathological responses to AChR, suggesting a lack of involvement of ERα in EAMG pathogenesis.

AB - Autoimmune myasthenia gravis (MG) is characterized by T cell and antibody responses to muscle nicotinic acetylcholine receptor (AChR). It is well known that MG as other autoimmune diseases is more prevalent in women than men and estrogen administration enhances experimental autoimmune MG (EAMG) severity. To determine whether estrogen influences EAMG pathogenesis through estrogen receptor alpha (ERα) activation, ERα knockout (KO) and wild-type (WT) C57BL/6 mice were immunized with AChR. ERα KO mice were equally susceptible to EAMG as WT mice and exhibited comparable antibody and immunopathological responses to AChR, suggesting a lack of involvement of ERα in EAMG pathogenesis.

KW - Autoimmunity

KW - Estrogen receptor alpha

KW - Myasthenia gravis

UR - http://www.scopus.com/inward/record.url?scp=79955648327&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955648327&partnerID=8YFLogxK

U2 - 10.1016/j.jneuroim.2011.03.002

DO - 10.1016/j.jneuroim.2011.03.002

M3 - Article

C2 - 21481948

AN - SCOPUS:79955648327

SN - 0165-5728

VL - 234

SP - 165

EP - 167

JO - Advances in Neuroimmunology

JF - Advances in Neuroimmunology

IS - 1-2

ER -

Genetic deficiency of estrogen receptor alpha fails to influence experimental autoimmune myasthenia gravis pathogenesis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this