Abstract
Autoimmune myasthenia gravis (MG) is characterized by T cell and antibody responses to muscle nicotinic acetylcholine receptor (AChR). It is well known that MG as other autoimmune diseases is more prevalent in women than men and estrogen administration enhances experimental autoimmune MG (EAMG) severity. To determine whether estrogen influences EAMG pathogenesis through estrogen receptor alpha (ERα) activation, ERα knockout (KO) and wild-type (WT) C57BL/6 mice were immunized with AChR. ERα KO mice were equally susceptible to EAMG as WT mice and exhibited comparable antibody and immunopathological responses to AChR, suggesting a lack of involvement of ERα in EAMG pathogenesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 165-167 |
| Number of pages | 3 |
| Journal | Journal of Neuroimmunology |
| Volume | 234 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - May 2011 |
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Keywords
- Autoimmunity
- Estrogen receptor alpha
- Myasthenia gravis
ASJC Scopus subject areas
- Immunology
- Clinical Neurology
- Immunology and Allergy
- Neurology
Cite this
Genetic deficiency of estrogen receptor alpha fails to influence experimental autoimmune myasthenia gravis pathogenesis. / Qi, Huibin; Li, Jing; Allman, Windy; Saini, Shamsher S.; Tüzün, Erdem; Wu, Xiaorong; Estes, D. Mark; Christadoss, Premkumar.
In: Journal of Neuroimmunology, Vol. 234, No. 1-2, 05.2011, p. 165-167.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Genetic deficiency of estrogen receptor alpha fails to influence experimental autoimmune myasthenia gravis pathogenesis
AU - Qi, Huibin
AU - Li, Jing
AU - Allman, Windy
AU - Saini, Shamsher S.
AU - Tüzün, Erdem
AU - Wu, Xiaorong
AU - Estes, D. Mark
AU - Christadoss, Premkumar
PY - 2011/5
Y1 - 2011/5
N2 - Autoimmune myasthenia gravis (MG) is characterized by T cell and antibody responses to muscle nicotinic acetylcholine receptor (AChR). It is well known that MG as other autoimmune diseases is more prevalent in women than men and estrogen administration enhances experimental autoimmune MG (EAMG) severity. To determine whether estrogen influences EAMG pathogenesis through estrogen receptor alpha (ERα) activation, ERα knockout (KO) and wild-type (WT) C57BL/6 mice were immunized with AChR. ERα KO mice were equally susceptible to EAMG as WT mice and exhibited comparable antibody and immunopathological responses to AChR, suggesting a lack of involvement of ERα in EAMG pathogenesis.
AB - Autoimmune myasthenia gravis (MG) is characterized by T cell and antibody responses to muscle nicotinic acetylcholine receptor (AChR). It is well known that MG as other autoimmune diseases is more prevalent in women than men and estrogen administration enhances experimental autoimmune MG (EAMG) severity. To determine whether estrogen influences EAMG pathogenesis through estrogen receptor alpha (ERα) activation, ERα knockout (KO) and wild-type (WT) C57BL/6 mice were immunized with AChR. ERα KO mice were equally susceptible to EAMG as WT mice and exhibited comparable antibody and immunopathological responses to AChR, suggesting a lack of involvement of ERα in EAMG pathogenesis.
KW - Autoimmunity
KW - Estrogen receptor alpha
KW - Myasthenia gravis
UR - http://www.scopus.com/inward/record.url?scp=79955648327&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79955648327&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2011.03.002
DO - 10.1016/j.jneuroim.2011.03.002
M3 - Article
C2 - 21481948
AN - SCOPUS:79955648327
VL - 234
SP - 165
EP - 167
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1-2
ER -