Genetic deficiency of estrogen receptor alpha fails to influence experimental autoimmune myasthenia gravis pathogenesis

Huibin Qi; Jing Li; Windy Allman; Shamsher S. Saini; Erdem Tüzün; Xiaorong Wu; D. Mark Estes; Premkumar Christadoss

doi:10.1016/j.jneuroim.2011.03.002

Genetic deficiency of estrogen receptor alpha fails to influence experimental autoimmune myasthenia gravis pathogenesis

Huibin Qi, Jing Li, Windy Allman, Shamsher S. Saini, Erdem Tüzün, Xiaorong Wu, D. Mark Estes, Premkumar Christadoss

Microbiology And Immunology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Autoimmune myasthenia gravis (MG) is characterized by T cell and antibody responses to muscle nicotinic acetylcholine receptor (AChR). It is well known that MG as other autoimmune diseases is more prevalent in women than men and estrogen administration enhances experimental autoimmune MG (EAMG) severity. To determine whether estrogen influences EAMG pathogenesis through estrogen receptor alpha (ERα) activation, ERα knockout (KO) and wild-type (WT) C57BL/6 mice were immunized with AChR. ERα KO mice were equally susceptible to EAMG as WT mice and exhibited comparable antibody and immunopathological responses to AChR, suggesting a lack of involvement of ERα in EAMG pathogenesis.

Original language	English (US)
Pages (from-to)	165-167
Number of pages	3
Journal	Journal of Neuroimmunology
Volume	234
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2011.03.002
State	Published - May 2011

Keywords

Autoimmunity
Estrogen receptor alpha
Myasthenia gravis

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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Genetic deficiency of estrogen receptor alpha fails to influence experimental autoimmune myasthenia gravis pathogenesis. / Qi, Huibin; Li, Jing; Allman, Windy; Saini, Shamsher S.; Tüzün, Erdem; Wu, Xiaorong; Estes, D. Mark; Christadoss, Premkumar.

In: Journal of Neuroimmunology, Vol. 234, No. 1-2, 05.2011, p. 165-167.

Research output: Contribution to journal › Article › peer-review

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title = "Genetic deficiency of estrogen receptor alpha fails to influence experimental autoimmune myasthenia gravis pathogenesis",

abstract = "Autoimmune myasthenia gravis (MG) is characterized by T cell and antibody responses to muscle nicotinic acetylcholine receptor (AChR). It is well known that MG as other autoimmune diseases is more prevalent in women than men and estrogen administration enhances experimental autoimmune MG (EAMG) severity. To determine whether estrogen influences EAMG pathogenesis through estrogen receptor alpha (ERα) activation, ERα knockout (KO) and wild-type (WT) C57BL/6 mice were immunized with AChR. ERα KO mice were equally susceptible to EAMG as WT mice and exhibited comparable antibody and immunopathological responses to AChR, suggesting a lack of involvement of ERα in EAMG pathogenesis.",

keywords = "Autoimmunity, Estrogen receptor alpha, Myasthenia gravis",

author = "Huibin Qi and Jing Li and Windy Allman and Saini, {Shamsher S.} and Erdem T{\"u}z{\"u}n and Xiaorong Wu and Estes, {D. Mark} and Premkumar Christadoss",

note = "Funding Information: We would like to thank Dr. Edward M. Curran for help in the breeding and genotyping of ERα KO mice. This work was supported by AFM .",

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AU - Qi, Huibin

AU - Li, Jing

AU - Allman, Windy

AU - Saini, Shamsher S.

AU - Tüzün, Erdem

AU - Wu, Xiaorong

AU - Estes, D. Mark

AU - Christadoss, Premkumar

N1 - Funding Information: We would like to thank Dr. Edward M. Curran for help in the breeding and genotyping of ERα KO mice. This work was supported by AFM .

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N2 - Autoimmune myasthenia gravis (MG) is characterized by T cell and antibody responses to muscle nicotinic acetylcholine receptor (AChR). It is well known that MG as other autoimmune diseases is more prevalent in women than men and estrogen administration enhances experimental autoimmune MG (EAMG) severity. To determine whether estrogen influences EAMG pathogenesis through estrogen receptor alpha (ERα) activation, ERα knockout (KO) and wild-type (WT) C57BL/6 mice were immunized with AChR. ERα KO mice were equally susceptible to EAMG as WT mice and exhibited comparable antibody and immunopathological responses to AChR, suggesting a lack of involvement of ERα in EAMG pathogenesis.

AB - Autoimmune myasthenia gravis (MG) is characterized by T cell and antibody responses to muscle nicotinic acetylcholine receptor (AChR). It is well known that MG as other autoimmune diseases is more prevalent in women than men and estrogen administration enhances experimental autoimmune MG (EAMG) severity. To determine whether estrogen influences EAMG pathogenesis through estrogen receptor alpha (ERα) activation, ERα knockout (KO) and wild-type (WT) C57BL/6 mice were immunized with AChR. ERα KO mice were equally susceptible to EAMG as WT mice and exhibited comparable antibody and immunopathological responses to AChR, suggesting a lack of involvement of ERα in EAMG pathogenesis.

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KW - Estrogen receptor alpha

KW - Myasthenia gravis

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Genetic deficiency of estrogen receptor alpha fails to influence experimental autoimmune myasthenia gravis pathogenesis

Abstract

Keywords

ASJC Scopus subject areas

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