Genetic divergence and dispersal of yellow fever virus, Brazil

Pedro F.C. Vasconcelos; Juliet E. Bryant; Amelia P.A. Travassos Da Rosa; Robert B. Tesh; Sueli G. Rodrigues; Alan D.T. Barrett

doi:10.3201/eid1009.040197

Genetic divergence and dispersal of yellow fever virus, Brazil

Pedro F.C. Vasconcelos, Juliet E. Bryant, Amelia P.A. Travassos Da Rosa, Robert B. Tesh, Sueli G. Rodrigues, Alan D.T. Barrett

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

An analysis of 79 yellow fever virus (YFV) isolates collected from 1935 to 2001 in Brazil showed a single genotype (South America I) circulating in the country, with the exception of a single strain from Rondônia, which represented South America genotype II. Brazilian YFV strains have diverged into two clades; an older clade appears to have become extinct and another has become the dominant lineage in recent years. Pairwise nucleotide diversity between strains ranged from 0% to 7.4%, while amino acid divergence ranged from 0% to 4.6%. Phylogenetic analysis indicated traffic of virus variants through large geographic areas and suggested that migration of infected people may be an important mechanism of virus dispersal. Isolation of vaccine virus from a patient with a fatal case suggests that vaccine-related illness may have been misdiagnosed in the past.

Original language	English (US)
Pages (from-to)	1578-1584
Number of pages	7
Journal	Emerging infectious diseases
Volume	10
Issue number	9
DOIs	https://doi.org/10.3201/eid1009.040197
State	Published - Sep 2004

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

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title = "Genetic divergence and dispersal of yellow fever virus, Brazil",

abstract = "An analysis of 79 yellow fever virus (YFV) isolates collected from 1935 to 2001 in Brazil showed a single genotype (South America I) circulating in the country, with the exception of a single strain from Rond{\^o}nia, which represented South America genotype II. Brazilian YFV strains have diverged into two clades; an older clade appears to have become extinct and another has become the dominant lineage in recent years. Pairwise nucleotide diversity between strains ranged from 0% to 7.4%, while amino acid divergence ranged from 0% to 4.6%. Phylogenetic analysis indicated traffic of virus variants through large geographic areas and suggested that migration of infected people may be an important mechanism of virus dispersal. Isolation of vaccine virus from a patient with a fatal case suggests that vaccine-related illness may have been misdiagnosed in the past.",

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AU - Vasconcelos, Pedro F.C.

AU - Bryant, Juliet E.

AU - Travassos Da Rosa, Amelia P.A.

AU - Tesh, Robert B.

AU - Rodrigues, Sueli G.

AU - Barrett, Alan D.T.

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Genetic divergence and dispersal of yellow fever virus, Brazil

Abstract

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