Genetic divergence and dispersal of yellow fever virus, Brazil

Pedro F C Vasconcelos, Juliet E. Bryant, Amelia P A Travassos Da Rosa, Robert B. Tesh, Sueli G. Rodrigues, Alan Barrett

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

An analysis of 79 yellow fever virus (YFV) isolates collected from 1935 to 2001 in Brazil showed a single genotype (South America I) circulating in the country, with the exception of a single strain from Rondônia, which represented South America genotype II. Brazilian YFV strains have diverged into two clades; an older clade appears to have become extinct and another has become the dominant lineage in recent years. Pairwise nucleotide diversity between strains ranged from 0% to 7.4%, while amino acid divergence ranged from 0% to 4.6%. Phylogenetic analysis indicated traffic of virus variants through large geographic areas and suggested that migration of infected people may be an important mechanism of virus dispersal. Isolation of vaccine virus from a patient with a fatal case suggests that vaccine-related illness may have been misdiagnosed in the past.

Original languageEnglish (US)
Pages (from-to)1578-1584
Number of pages7
JournalEmerging Infectious Diseases
Volume10
Issue number9
StatePublished - Sep 2004

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Yellow fever virus
Brazil
South America
Viruses
Vaccines
Genotype
Diagnostic Errors
Nucleotides
Amino Acids

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Vasconcelos, P. F. C., Bryant, J. E., Travassos Da Rosa, A. P. A., Tesh, R. B., Rodrigues, S. G., & Barrett, A. (2004). Genetic divergence and dispersal of yellow fever virus, Brazil. Emerging Infectious Diseases, 10(9), 1578-1584.

Genetic divergence and dispersal of yellow fever virus, Brazil. / Vasconcelos, Pedro F C; Bryant, Juliet E.; Travassos Da Rosa, Amelia P A; Tesh, Robert B.; Rodrigues, Sueli G.; Barrett, Alan.

In: Emerging Infectious Diseases, Vol. 10, No. 9, 09.2004, p. 1578-1584.

Research output: Contribution to journalArticle

Vasconcelos, PFC, Bryant, JE, Travassos Da Rosa, APA, Tesh, RB, Rodrigues, SG & Barrett, A 2004, 'Genetic divergence and dispersal of yellow fever virus, Brazil', Emerging Infectious Diseases, vol. 10, no. 9, pp. 1578-1584.
Vasconcelos PFC, Bryant JE, Travassos Da Rosa APA, Tesh RB, Rodrigues SG, Barrett A. Genetic divergence and dispersal of yellow fever virus, Brazil. Emerging Infectious Diseases. 2004 Sep;10(9):1578-1584.
Vasconcelos, Pedro F C ; Bryant, Juliet E. ; Travassos Da Rosa, Amelia P A ; Tesh, Robert B. ; Rodrigues, Sueli G. ; Barrett, Alan. / Genetic divergence and dispersal of yellow fever virus, Brazil. In: Emerging Infectious Diseases. 2004 ; Vol. 10, No. 9. pp. 1578-1584.
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