Genetic diversity among Bolivian arenaviruses

Maria N B Cajimat, Mary Louise Milazzo, Pierre E. Rollin, Stuart T. Nichol, Michael D. Bowen, Thomas Ksiazek, Charles F. Fulhorst

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Machupo virus and Chapare virus are members of the Tacaribe serocomplex (virus family Arenaviridae) and etiological agents of hemorrhagic fever in humans in Bolivia. The nucleotide sequences of the complete Z genes, a large fragment of the RNA-dependent RNA polymerase genes, the complete glycoprotein precursor genes, and the complete nucleocapsid protein genes of 8 strains of Machupo virus were determined to increase our knowledge of the genetic diversity among the Bolivian arenaviruses. The results of analyses of the predicted amino acid sequences of the glycoproteins of the Machupo virus strains and Chapare virus strain 200001071 indicated that immune plasma from hemorrhagic fever cases caused by Machupo virus may prove beneficial in the treatment of Bolivian hemorrhagic fever but not hemorrhagic fever caused by Chapare virus.

Original languageEnglish (US)
Pages (from-to)24-31
Number of pages8
JournalVirus Research
Volume140
Issue number1-2
DOIs
StatePublished - Mar 2009
Externally publishedYes

Fingerprint

New World Arenaviruses
Arenavirus
Fever
Genes
American Hemorrhagic Fever
Arenaviridae
Glycoproteins
Bolivia
RNA Replicase
Nucleocapsid Proteins
Protein Sequence Analysis

Keywords

  • Arenaviridae
  • Bolivian hemorrhagic fever
  • Chapare virus
  • Latino virus
  • Machupo virus

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases
  • Cancer Research

Cite this

Cajimat, M. N. B., Milazzo, M. L., Rollin, P. E., Nichol, S. T., Bowen, M. D., Ksiazek, T., & Fulhorst, C. F. (2009). Genetic diversity among Bolivian arenaviruses. Virus Research, 140(1-2), 24-31. https://doi.org/10.1016/j.virusres.2008.10.016

Genetic diversity among Bolivian arenaviruses. / Cajimat, Maria N B; Milazzo, Mary Louise; Rollin, Pierre E.; Nichol, Stuart T.; Bowen, Michael D.; Ksiazek, Thomas; Fulhorst, Charles F.

In: Virus Research, Vol. 140, No. 1-2, 03.2009, p. 24-31.

Research output: Contribution to journalArticle

Cajimat, MNB, Milazzo, ML, Rollin, PE, Nichol, ST, Bowen, MD, Ksiazek, T & Fulhorst, CF 2009, 'Genetic diversity among Bolivian arenaviruses', Virus Research, vol. 140, no. 1-2, pp. 24-31. https://doi.org/10.1016/j.virusres.2008.10.016
Cajimat MNB, Milazzo ML, Rollin PE, Nichol ST, Bowen MD, Ksiazek T et al. Genetic diversity among Bolivian arenaviruses. Virus Research. 2009 Mar;140(1-2):24-31. https://doi.org/10.1016/j.virusres.2008.10.016
Cajimat, Maria N B ; Milazzo, Mary Louise ; Rollin, Pierre E. ; Nichol, Stuart T. ; Bowen, Michael D. ; Ksiazek, Thomas ; Fulhorst, Charles F. / Genetic diversity among Bolivian arenaviruses. In: Virus Research. 2009 ; Vol. 140, No. 1-2. pp. 24-31.
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