Genetic diversity among Bolivian arenaviruses

Maria N.B. Cajimat, Mary Louise Milazzo, Pierre E. Rollin, Stuart T. Nichol, Michael D. Bowen, Thomas G. Ksiazek, Charles F. Fulhorst

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Machupo virus and Chapare virus are members of the Tacaribe serocomplex (virus family Arenaviridae) and etiological agents of hemorrhagic fever in humans in Bolivia. The nucleotide sequences of the complete Z genes, a large fragment of the RNA-dependent RNA polymerase genes, the complete glycoprotein precursor genes, and the complete nucleocapsid protein genes of 8 strains of Machupo virus were determined to increase our knowledge of the genetic diversity among the Bolivian arenaviruses. The results of analyses of the predicted amino acid sequences of the glycoproteins of the Machupo virus strains and Chapare virus strain 200001071 indicated that immune plasma from hemorrhagic fever cases caused by Machupo virus may prove beneficial in the treatment of Bolivian hemorrhagic fever but not hemorrhagic fever caused by Chapare virus.

Original languageEnglish (US)
Pages (from-to)24-31
Number of pages8
JournalVirus Research
Volume140
Issue number1-2
DOIs
StatePublished - Mar 1 2009
Externally publishedYes

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Keywords

  • Arenaviridae
  • Bolivian hemorrhagic fever
  • Chapare virus
  • Latino virus
  • Machupo virus

ASJC Scopus subject areas

  • Cancer Research
  • Virology
  • Infectious Diseases

Cite this

Cajimat, M. N. B., Milazzo, M. L., Rollin, P. E., Nichol, S. T., Bowen, M. D., Ksiazek, T. G., & Fulhorst, C. F. (2009). Genetic diversity among Bolivian arenaviruses. Virus Research, 140(1-2), 24-31. https://doi.org/10.1016/j.virusres.2008.10.016