Genetic diversity and distribution of Peromyscus-borne hantaviruses in North America

Martha C. Monroe, Sergey P. Morzunov, Angela M. Johnson, Michael D. Bowen, Harvey Artsob, Terry Yates, C. J. Peters, Pierre E. Rollin, Thomas Ksiazek, Stuart T. Nichol

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

The 1993 outbreak of hantavirus pulmonary syndrome (HPS) in the southwestern United States was associated with Sin Nombre virus, a rodent- borne hantavirus; The virus' primary reservoir is the deer mouse (Peromyscus maniculatus). Hantavirus-infected rodents were identified in various regions of North America. An extensive nucleotide sequence database of an 139 bp fragment amplified from virus M genomic segments was generated. Phylogenetic analysis confirmed that SNV-like hantaviruses are widely distributed in Peromyscus species rodents throughout North America. Classic SNV is the major cause of HPS in North America, but other Peromyscine-borne hantaviruses, e.g., New York and Monongahela viruses, are also associated with HPS cases. Although genetically diverse, SNV-like viruses have slowly coevolved with their rodent hosts. We show that the genetic relationships of hantaviruses in the Americas are complex, most likely as a result of the rapid radiation and speciation of New World sigmodontine rodents and occasional virus-host switching events.

Original languageEnglish
Pages (from-to)75-86
Number of pages12
JournalEmerging Infectious Diseases
Volume5
Issue number1
StatePublished - 1999
Externally publishedYes

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Peromyscus
Hantavirus
North America
Hantavirus Pulmonary Syndrome
Rodentia
Viruses
Sin Nombre virus
Southwestern United States
Disease Outbreaks
Databases
Radiation

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Monroe, M. C., Morzunov, S. P., Johnson, A. M., Bowen, M. D., Artsob, H., Yates, T., ... Nichol, S. T. (1999). Genetic diversity and distribution of Peromyscus-borne hantaviruses in North America. Emerging Infectious Diseases, 5(1), 75-86.

Genetic diversity and distribution of Peromyscus-borne hantaviruses in North America. / Monroe, Martha C.; Morzunov, Sergey P.; Johnson, Angela M.; Bowen, Michael D.; Artsob, Harvey; Yates, Terry; Peters, C. J.; Rollin, Pierre E.; Ksiazek, Thomas; Nichol, Stuart T.

In: Emerging Infectious Diseases, Vol. 5, No. 1, 1999, p. 75-86.

Research output: Contribution to journalArticle

Monroe, MC, Morzunov, SP, Johnson, AM, Bowen, MD, Artsob, H, Yates, T, Peters, CJ, Rollin, PE, Ksiazek, T & Nichol, ST 1999, 'Genetic diversity and distribution of Peromyscus-borne hantaviruses in North America', Emerging Infectious Diseases, vol. 5, no. 1, pp. 75-86.
Monroe MC, Morzunov SP, Johnson AM, Bowen MD, Artsob H, Yates T et al. Genetic diversity and distribution of Peromyscus-borne hantaviruses in North America. Emerging Infectious Diseases. 1999;5(1):75-86.
Monroe, Martha C. ; Morzunov, Sergey P. ; Johnson, Angela M. ; Bowen, Michael D. ; Artsob, Harvey ; Yates, Terry ; Peters, C. J. ; Rollin, Pierre E. ; Ksiazek, Thomas ; Nichol, Stuart T. / Genetic diversity and distribution of Peromyscus-borne hantaviruses in North America. In: Emerging Infectious Diseases. 1999 ; Vol. 5, No. 1. pp. 75-86.
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